溶瘤病毒疗法治疗犬猫肿瘤。
Oncolytic virotherapy of canine and feline cancer.
机构信息
Department of Biochemistry, University of Wuerzburg, Wuerzburg D-97074, Germany.
Genelux Corporation, San Diego Science Center, San Diego, CA 92109, USA.
出版信息
Viruses. 2014 May 16;6(5):2122-37. doi: 10.3390/v6052122.
Abstract
Cancer is the leading cause of disease-related death in companion animals such as dogs and cats. Despite recent progress in the diagnosis and treatment of advanced canine and feline cancer, overall patient treatment outcome has not been substantially improved. Virotherapy using oncolytic viruses is one promising new strategy for cancer therapy. Oncolytic viruses (OVs) preferentially infect and lyse cancer cells, without causing excessive damage to surrounding healthy tissue, and initiate tumor-specific immunity. The current review describes the use of different oncolytic viruses for cancer therapy and their application to canine and feline cancer.
摘要
癌症是犬猫等伴侣动物疾病相关死亡的主要原因。尽管在犬猫晚期癌症的诊断和治疗方面取得了一些新的进展，但整体患者治疗效果并没有得到实质性的提高。溶瘤病毒治疗是癌症治疗的一种很有前途的新策略。溶瘤病毒（OV）能够选择性地感染和裂解癌细胞，而不会对周围健康组织造成过度损伤，并能引发肿瘤特异性免疫。本文综述了不同溶瘤病毒在癌症治疗中的应用，并介绍了其在犬猫癌症治疗中的应用。
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