Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA.
The Trust Hospital, Accra, Ghana.
J Perinatol. 2019 May;39(5):697-707. doi: 10.1038/s41372-019-0352-7. Epub 2019 Mar 25.
To examine the temporal trends in the incidence and outcomes of neonatal herpes simplex infections (NHSV) in the United States.
We conducted a retrospective study using the National Inpatient Sample (NIS). Neonates ≤28 days old with ICD-9 codes for NHSV (054.xx) from 2003 to 2014 were included. Trends in the incidence, mortality, length of stay (LOS), and hospital cost were analyzed using Jonckheere-Terpstra test.
NHSV increased from 7.9 to 10 per 100,000 live births from 2003-05 to 2012-14 (P = 0.04). Hospital costs increased from $21,650 to $27,843; P < 0.001). The overall mortality rate and median LOS were 7.9% and 20 days, respectively and there were no significant variations across years during the study period.
The incidence of NHSV in the United States increased between 2003 and 2014 without a significant change in mortality. NHSV remains a serious health threat and new and effective strategies to prevent NHSV are needed.
研究美国新生儿单纯疱疹病毒感染（NHSV）的发病率和结局的时间趋势。
我们使用国家住院患者样本（NIS）进行了回顾性研究。纳入 2003 年至 2014 年间，ICD-9 编码为 NHSV（054.xx）的≤28 天新生儿。使用 Jonckheere-Terpstra 检验分析发病率、死亡率、住院时间（LOS）和住院费用的趋势。
从 2003-05 年到 2012-14 年，NHSV 的发病率从每 100,000 例活产 7.9 例增加到每 100,000 例活产 10 例（P=0.04）。住院费用从 21,650 美元增加到 27,843 美元；P<0.001）。总死亡率和中位数 LOS 分别为 7.9%和 20 天，研究期间各年无显著变化。
2003 年至 2014 年间，美国 NHSV 的发病率增加，而死亡率没有明显变化。NHSV 仍然是一个严重的健康威胁，需要新的和有效的策略来预防 NHSV。
