Fan Xin, Fan Yan-Ting, Zeng Hui, Dong Xi-Qi, Lu Min, Zhang Zhi-Yuan
Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi Province, China.
The First Clinical Medical College, Nanchang University, Nanchang 330000, Jiangxi Province, China.
World J Gastrointest Oncol. 2023 Jul 15;15(7):1105-1118. doi: 10.4251/wjgo.v15.i7.1105.
Esophageal cancer (EC) is one of the most common digestive system malignancies in the world. The combined modality treatment of EC is usually surgery and radiation therapy, however, its clinical efficacy for advanced patients is relatively limited. Ferroptosis, a new type of iron-dependent programmed cell death, is different from apoptosis, necrosis and autophagy. In recent years, many studies have further enlightened that ferroptosis plays an essential role in the occurrence, development and metastasis of tumors. Targeting ferroptosis stimulates a new direction for further exploration of oncologic treatment regimens. Furthermore, ferroptosis has a critical role in the immune microenvironment of tumors. This paper reviews the mechanism of ferroptosis and the ferroptosis research progress in the treatment of EC. We further elaborate the interaction between ferroptosis and immunotherapy, and the related mechanisms of ferroptosis participation in the immunotherapy of EC, so as to provide new directions and ideas for the treatment of EC.
食管癌（EC）是世界上最常见的消化系统恶性肿瘤之一。EC的综合治疗方式通常是手术和放射治疗，然而，其对晚期患者的临床疗效相对有限。铁死亡是一种新型的铁依赖性程序性细胞死亡，不同于凋亡、坏死和自噬。近年来，许多研究进一步表明，铁死亡在肿瘤的发生、发展和转移中起着至关重要的作用。靶向铁死亡为进一步探索肿瘤治疗方案开辟了新方向。此外，铁死亡在肿瘤免疫微环境中也起着关键作用。本文综述了铁死亡的机制以及铁死亡在EC治疗中的研究进展。我们进一步阐述了铁死亡与免疫治疗之间的相互作用，以及铁死亡参与EC免疫治疗的相关机制，以期为EC的治疗提供新的方向和思路。
