Jemal Ahmedin, Schafer Elizabeth J, Star Jessica, Bandi Priti, Sung Hyuna, Islami Farhad, Siegel Rebecca L
Surveillance and Health Equity Science, American Cancer Society, Atlanta, Georgia, USA.
Int J Cancer. 2025 Feb 1;156(3):499-504. doi: 10.1002/ijc.35188. Epub 2024 Oct 11.
Previous studies reported higher lung cancer incidence in women than men among persons aged 35-54 years in the United States, a reversal of historically higher rates in men. We examined whether this pattern varies by state. Based on lung cancer incidence (2015-2019) data among adults aged 35-54 years from Cancer in North America database and historical cigarette smoking prevalence data (2004-2005) among adults 20-39 years from the Behavioral Risk Factor Surveillance System, incidence rates in women were equal to or higher than rates in their male counterparts in 40 of 51 states, with statistically significant differences in 20 states (two-sided, p < .05). In contrast, current and ever smoking prevalence in women compared to men was statistically significantly lower (33 and 34 states, respectively) or similar. Furthermore, there was no association between differences in historical smoking prevalence and lung cancer incidence by sex. Lung cancer incidence rate is higher in young women than young men in most states and is unexplained by differences in smoking prevalence.
以往研究报告称，在美国35至54岁人群中，女性肺癌发病率高于男性，这与历史上男性肺癌发病率较高的情况相反。我们研究了这种模式是否因州而异。基于北美癌症数据库中35至54岁成年人的肺癌发病率（2015 - 2019年）数据以及行为风险因素监测系统中20至39岁成年人的历史吸烟流行率数据（2004 - 2005年），在51个州中的40个州，女性发病率等于或高于男性，其中20个州存在统计学显著差异（双侧，p < 0.05）。相比之下，女性当前吸烟率和曾经吸烟率与男性相比，在统计学上显著更低（分别为33个州和34个州）或相似。此外，历史吸烟流行率差异与按性别划分的肺癌发病率之间没有关联。在大多数州，年轻女性的肺癌发病率高于年轻男性，且无法用吸烟流行率差异来解释。
