IVI Barcelona, 08017 Barcelona, Spain.
Universidad Europea (Campus Alcobendas), 28108 Alcobendas, Spain.
Rev Int Androl. 2024 Sep;22(3):16-23. doi: 10.22514/j.androl.2024.018. Epub 2024 Sep 30.
Platelet-Rich Plasma (PRP) is a regenerative therapy that has gained interest in recent years, being the subject of various studies and applications. In the field of human reproduction specifically, there are growth factors (GFs) present in PRP that have shown an impact on sperm quality and function. The main objective of this article is to conduct a literature review on the use of PRP for the treatment of male infertility. To achieve this, a bibliographic search of articles and reviews in scientific journals about the possible use of PRP for the treatment of male factor published between 2018 and 2023 has been carried out. Nine publications were identified, proposing the application of PRP in the following areas: sperm cryopreservation, oxidative stress, culture of spermatogonial stem cells, and secretory azoospermia. According to the literature, supplementing the cryopreservation medium with PRP improves sperm parameters, and samples incubated with PRP show an increase in their antioxidant capacity. Finally, PRP can increase the proliferation and vitality of spermatogonial stem cells and sperm recovery in cases of non-obstructive azoospermia. PRP shows therapeutic potential in various aspects of the male factor. Further research with a larger sample size is needed to define both its protocols and its clinical efficacy.
富血小板血浆（PRP）是一种再生疗法，近年来引起了人们的兴趣，成为了各种研究和应用的主题。特别是在人类生殖领域，PRP 中存在的生长因子（GFs）已被证明对精子质量和功能有影响。本文的主要目的是对 PRP 治疗男性不育症的应用进行文献综述。为此，对 2018 年至 2023 年间发表的关于 PRP 治疗男性因素的可能用途的科学期刊文章和综述进行了文献检索。确定了 9 篇出版物，提出了将 PRP 应用于以下领域：精子冷冻保存、氧化应激、精原干细胞培养和分泌性无精子症。根据文献，在冷冻保存培养基中添加 PRP 可以改善精子参数，与 PRP 孵育的样本显示其抗氧化能力增加。最后，PRP 可以增加非梗阻性无精子症患者的精原干细胞的增殖和活力，并恢复精子。PRP 在男性因素的各个方面都显示出治疗潜力。需要进行更大样本量的进一步研究，以确定其方案和临床疗效。
