Hou Shuxian, Hong Ye, Shang Jihua, Wang Yimei, Shi Xuechao, Liu Xinxin, Yang Guoqiang, Wang Yuxuan, Ge Fei, Xiao Yao, Kaoutar Chaldi, Wu Yuan, Wang Jun
School of Biological and food Engineering, Anhui Polytechnic University, Wuhu, Anhui 241000, China.
Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province 210006, China.
Colloids Surf B Biointerfaces. 2025 Jan;245:114288. doi: 10.1016/j.colsurfb.2024.114288. Epub 2024 Oct 5.
The misuse of antibiotics has led to the growing problem of multidrug-resistant (MDR) bacteria, and there is still a lack of effective antibacterial agents that can replace antibiotics. Therefore, the design and development of multifunctional nanomaterials with long-term inhibitory effects on drug-resistant bacteria are extremely challenging. In this study, a multifunctional biomimetic self-assembly system, BSA-ZnO&Quercetin, based on bovine serum albumin (BSA), ZnO, and quercetin, was established using a simple and controllable method. The prepared self-assembly system has high stability and biocompatibility, and could fully combine the performance advantages of each component. BSA-ZnO&Quercetin showed excellent broad-spectrum antibacterial activity without inducing bacterial resistance. The related antibacterial mechanism of BSA-ZnO&Quercetin primarily involves biofilm inhibition and destruction, and inducing the production of reactive oxygen species, resulting in the death of the bacteria. The biomimetic self-assembly system BSA-ZnO&Quercetin constructed in this research is expected to replace antibiotics for antibacterial application.
抗生素的滥用导致了多重耐药（MDR）细菌这一日益严重的问题，并且仍然缺乏能够替代抗生素的有效抗菌剂。因此，设计和开发对耐药细菌具有长期抑制作用的多功能纳米材料极具挑战性。在本研究中，基于牛血清白蛋白（BSA）、氧化锌（ZnO）和槲皮素，采用简单可控的方法建立了一种多功能仿生自组装体系BSA-ZnO&槲皮素。所制备的自组装体系具有高稳定性和生物相容性，并且能够充分结合各组分的性能优势。BSA-ZnO&槲皮素表现出优异的广谱抗菌活性且不会诱导细菌耐药性。BSA-ZnO&槲皮素的相关抗菌机制主要涉及生物膜抑制和破坏，以及诱导活性氧的产生，从而导致细菌死亡。本研究构建的仿生自组装体系BSA-ZnO&槲皮素有望替代抗生素用于抗菌应用。
