利用天然深共晶溶剂（NADES）可持续分离具有良好毒理学特性的生姜（Zingiber officinale）药尘生物活性化合物。
Sustainable isolation of ginger (Zingiber officinale) herbal dust bioactive compounds with favorable toxicological profile employing natural deep eutectic solvents (NADES).
机构信息
Department of Pharmaceutical Engineering, Faculty of Technology Novi Sad, University of Novi Sad, Boulevard Cara Lazara 1, 21000 Novi Sad, Serbia; Laboratory for Cell Culture Technology and Biotransformations, Department of Biochemical Engineering, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierotti Street 6, 10000 Zagreb, Croatia.
Laboratory for Cell Culture Technology and Biotransformations, Department of Biochemical Engineering, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierotti Street 6, 10000 Zagreb, Croatia.
出版信息
Food Chem. 2025 Feb 1;464(Pt 1):141545. doi: 10.1016/j.foodchem.2024.141545. Epub 2024 Oct 5.
The usage of ginger (Zingiber officinale) has increased in recent years due to its positive effect on human health affiliated with its richness in gingerols and shogaols. This study optimized the Ultrasound-assisted extraction (UAE) for better phenolic compounds isolation from ginger herbal dust (GHD), a filter tea industry by-product. The extraction was performed using raw and defatted GHD-previously processed by Supercritical fluid extraction - CO. An additional advantage was using COSMOtherm software for 71 natural deep eutectic solvents (NADES) screening, to select the optimal one for GHD 6-gingerol recovery. As an optimal NADES, Malic acid:Glucose (MA:Glc) in the 1:1 ratio was determined. The optimal MA: Glc-based extract with a 6-gingerol content of 1.90±0.05 mg/g, an antioxidant activity of 321.28±5.09 μmol TE/g, and a favorable toxicological profile was obtained in 2 min of UAE under the sonication amplitude of 20 %, approving the benefits and the sustainability of the present study.
近年来，由于姜（Zingiber officinale）中的姜醇和姜烯酚对人体健康有积极影响，其使用量有所增加。本研究通过超声辅助提取（UAE），从过滤茶工业的副产品——生姜药渣（GHD）中更好地分离酚类化合物，对其进行了优化。提取过程使用未经处理和脱脂的 GHD（之前已用超临界 CO2 流体萃取预处理）。此外，还使用 COSMOtherm 软件对 71 种天然深共熔溶剂（NADES）进行了筛选，以选择用于 GHD 6-姜酚回收的最佳溶剂。作为一种优化的 NADES，确定了 1:1 比例的苹果酸：葡萄糖（MA：Glc）。在超声幅度为 20%、2 分钟的 UAE 条件下，得到了最佳的 MA：Glc 基提取物，其 6-姜酚含量为 1.90±0.05 mg/g，抗氧化活性为 321.28±5.09 μmol TE/g，且具有良好的毒理学特性，证实了本研究的优势和可持续性。
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