Rahman Mujeeb Ur, Ullah Muhammad Wajid, Alabbosh Khulood Fahad, Shah Junaid Ali, Muhammad Nizar, Shah Syed Waqas Ali, Nawab Said, Sethupathy Sivasamy, Abdikakharovich Sidikov Akmal, Khan Khalid Ali, Elboughdiri Noureddine, Zhu Daochen
Biofuels Institute, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, PR China; Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment, Suzhou University of Science and Technology, Suzhou 215009, PR China.
Department of Pulp & Paper Engineering, College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
Int J Biol Macromol. 2024 Nov;281(Pt 3):136383. doi: 10.1016/j.ijbiomac.2024.136383. Epub 2024 Oct 11.
The increasing interest in lignin, a complex and abundant biopolymer, stems from its ability to produce environmentally beneficial biobased products. β-Etherases play a crucial role by breaking down the β-aryl ether bonds in lignin. This comprehensive review covers the latest advancements in β-etherase-mediated lignin valorization, focusing on substrate selectivity, enzymatic oxidative activity, and engineering methods. Research on the microbial origin, protein modification, and molecular structure determination of β-etherases has improved our understanding of their effectiveness. Furthermore, the use of these enzymes in biorefinery processes is promising for enhancing lignin breakdown and creating more valuable products. The review also discusses the challenges and future potential of β-etherases in advancing lignin valorization for biorefinery applications that are economically viable and environmentally sustainable.
人们对木质素（一种复杂且丰富的生物聚合物）的兴趣与日俱增，这源于它能够生产对环境有益的生物基产品。β-醚酶通过分解木质素中的β-芳基醚键发挥关键作用。这篇综述涵盖了β-醚酶介导的木质素增值的最新进展，重点关注底物选择性、酶促氧化活性和工程方法。对β-醚酶的微生物来源、蛋白质修饰和分子结构测定的研究增进了我们对其有效性的理解。此外，在生物精炼过程中使用这些酶有望增强木质素的分解并创造更有价值的产品。该综述还讨论了β-醚酶在推进木质素增值以用于经济可行且环境可持续的生物精炼应用方面所面临的挑战和未来潜力。
