Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
BMJ Open. 2024 Oct 11;14(10):e083011. doi: 10.1136/bmjopen-2023-083011.
Nerve sheath tumours arise from both the central and peripheral nervous systems. In particular, cases of spinal or paraspinal origins are scarce and poorly covered in the literature. This systematic review aims to summarise the body of evidence regarding spinal nerve sheath tumours and assess its quality, to provide the current knowledge on epidemiology, tumour characteristics, diagnostics, treatment strategies and outcomes.
Databases including PubMed, Web of Science and Embase will be searched using keywords such as "spinal", "nerve sheath", "neurofibroma", "schwannoma", "neurinoma" and "neurilemoma". The search will be limited to studies published no earlier than 2000 without language restrictions. Case reports, editorials, letters and reviews will be excluded. Reference lists of identified studies will be searched to find possible additional relevant records. Identified studies will be screened for inclusion, by one reviewer at first and then two independent ones in the next step to increase the external validity. The Rayyan platform will be used for the screening and inclusion process. Data extraction within several predetermined areas of interest will proceed. Subjects of interest include epidemiology, histopathology, radiological diagnostics, surgery, complications, non-surgical treatment alternatives, disease outcomes and predictors of outcome, and recurrence rates. On satisfactory amount of homogenous data, a meta-analysis of key outcomes such as recurrence risk or postoperative neurological improvement will be performed. This systematic review will primarily serve as a reference guide to aid in diagnosis and treatment of patients with spinal schwannomas, while also spotlighting the knowledge gaps in the literature to help guide future research initiatives.
Ethics approval is not required for the protocol or review as both are based on existing publications. For dissemination, the final manuscript will be submitted to a peer-reviewed journal.
神经鞘瘤起源于中枢和周围神经系统。特别是，脊柱或脊柱旁起源的病例很少，文献中也很少涉及。本系统综述旨在总结有关脊柱神经鞘瘤的证据，并评估其质量，以提供有关流行病学、肿瘤特征、诊断、治疗策略和结果的最新知识。
将使用关键词（如“脊柱”、“神经鞘”、“神经纤维瘤”、“施万细胞瘤”、“神经瘤”和“神经鞘瘤”）在 PubMed、Web of Science 和 Embase 等数据库中进行搜索。搜索将限于 2000 年以前发表的、无语言限制的研究。将排除病例报告、社论、信件和综述。将检索已确定研究的参考文献列表，以查找可能的其他相关记录。通过一位评审员首先对确定的研究进行筛选，然后在下一步由两位独立评审员进行筛选，以提高外部有效性。将使用 Rayyan 平台进行筛选和纳入过程。将在几个预先确定的感兴趣领域内进行数据提取。感兴趣的主题包括流行病学、组织病理学、放射学诊断、手术、并发症、非手术治疗选择、疾病结果和预后预测以及复发率。在具有足够同质数据的情况下，将对关键结果（如复发风险或术后神经功能改善）进行荟萃分析。本系统综述主要作为诊断和治疗脊柱施万细胞瘤患者的参考指南，同时突出文献中的知识空白，以帮助指导未来的研究计划。
该方案或综述不需要伦理批准，因为两者都是基于现有出版物的。对于传播，最终手稿将提交给同行评审期刊。
