Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden
Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
BMJ Open. 2022 Jun 23;12(6):e061614. doi: 10.1136/bmjopen-2022-061614.
Meningiomas are primary central nervous system tumours that arise from both cranial and spinal meninges. Spinal meningiomas occur less frequently than their cranial counterparts and are consequently given less attention in the literature. Therefore, systematic studies are needed to summarise the current knowledge on spinal meningiomas, providing a solid evidence base for treatment strategies. This systematic review of the literature will therefore assess studies describing spinal meningiomas, their epidemiology, diagnostics, treatment and outcomes.
Electronic databases, including PubMed, Web of Science and Embase, will be searched using the keywords "spinal" and "meningioma". The search will be set to provide only English studies published after 2000 to avoid any conflicts regarding terminology and classification, as well as to reflect the current status. Case reports, editorials, letters and reviews will also be excluded. Reference lists of relevant records will also be searched. Identified studies will be screened for inclusion, by one reviewer in a first step and then three in the next step to decrease the risk of bias. The results will be categorised to allow for a structured summary of the outcomes and their evidence grade conforming to the Grading of Recommendations, Assessment, Development and Evaluation approach. Categories may include: epidemiology, histopathology, radiological diagnostics, surgery, complications, non-surgical or adjuvant treatments, disease outcomes and predictors, and lastly recurrence. This review will summarise the current knowledge on spinal meningiomas to allow for a better understanding of the disease and contribute to improve its management. For clinicians, the systematic collection and grading of available evidence may aid in decision making and for those seeking to further the scientific field, this review may help to identify areas where knowledge is currently lacking.
Ethics approval was not required for our systematic review as it is based on existing publications. The results will be disseminated via submission for publication in a peer-reviewed journal.
脑膜瘤是一种起源于颅内外脑膜的原发性中枢神经系统肿瘤。脊髓脑膜瘤的发病率低于颅腔脑膜瘤，因此在文献中受到的关注较少。因此，需要进行系统研究来总结脊髓脑膜瘤的现有知识，为治疗策略提供坚实的证据基础。本系统文献复习将评估描述脊髓脑膜瘤、其流行病学、诊断、治疗和结局的研究。
将使用“spinal”和“meningioma”这两个关键词在电子数据库（包括 PubMed、Web of Science 和 Embase）中进行搜索。搜索范围将设置为仅提供 2000 年后发表的英文研究，以避免术语和分类方面的任何冲突，并反映当前的现状。也将排除病例报告、社论、信件和评论。还将搜索相关记录的参考文献列表。由一名评审员在第一步筛选符合纳入标准的研究，然后由另外三名评审员在下一步筛选，以降低偏倚风险。将结果进行分类，以便按照推荐、评估、开发和评估方法的分级原则，对结果及其证据等级进行结构化总结。类别可能包括：流行病学、组织病理学、放射学诊断、手术、并发症、非手术或辅助治疗、疾病结局和预测因素，以及最后复发。本综述将总结脊髓脑膜瘤的现有知识，以便更好地了解该疾病，并有助于改善其治疗。对于临床医生，系统地收集和分级现有证据可能有助于决策，对于那些寻求进一步发展科学领域的人来说，本综述可能有助于确定目前知识匮乏的领域。
由于本系统综述基于现有出版物，因此不需要伦理批准。研究结果将通过提交给同行评议期刊发表来传播。
