VaccinDirekt Sverige AB, Slussplan 7, Stockholm, 111 30, Sweden.
Bavarian Nordic Switzerland AG, Grafenauweg 8, Zug, CH-6301, Switzerland.
BMC Infect Dis. 2024 Oct 13;24(1):1151. doi: 10.1186/s12879-024-10045-4.
We explored vaccine motivation and preferences for tick-borne encephalitis (TBE) vaccine attributes among participants in TBE-endemic countries in Europe.
An online survey was conducted among the general public in Austria, Germany, Switzerland, and Sweden. Participants were ≥ 18 years old, open to receiving vaccines, and living in, or regularly traveling to, TBE-endemic regions in the aforementioned countries. Participants were asked about their general vaccine knowledge and motivations for vaccination, before rating the importance of TBE vaccine attributes, such as efficacy, safety, dosing schedule, and booster interval. Thereafter, participants were shown three hypothetical TBE vaccine profiles with different combinations of attributes. Assuming equal efficacy and safety, participants were asked to select their preferred profile from 12 screens as part of a discrete-choice conjoint analysis. Utility scores were calculated to show the importance of each attribute. Data are presented for the overall survey group and by age and gender, using t-tests to compare means.
For 73% of participants (n = 1003/1379), self-protection was among the top three reasons to get vaccinated. Disease severity, protection of children or family, and advice or recommendation from a doctor/healthcare professional (HCP) were top three reasons for over half of participants. The majority (58-69%) agreed or strongly agreed that they trust their doctor/HCP on the subject of vaccines, they rely on their doctor/HCP's vaccine knowledge, and they prefer their doctor/HCP to make recommendations on which vaccines they or their families should take. Efficacy and safety were the most important standalone TBE vaccine attributes; however, among TBE vaccine profiles including 3-, 5- and 10-year booster intervals, the 10-year booster interval was the most influential attribute level when choosing a preferred vaccine profile (utility score: 0.58 [standard error: 0.01]). Differences in motivators and preferences were observed between age and gender subgroups.
The high level of doctor/HCP reliance highlights the key role doctors/HCPs play in influencing vaccine decision-making. Booster interval was the biggest driver of choice when selecting a hypothetical TBE vaccine profile, with the strongest preference for a 10-year booster interval. These findings could be used to inform TBE vaccination recommendations and in the further development of TBE vaccines.
我们研究了在欧洲蜱传脑炎（TBE）流行国家的参与者中，TBE 疫苗接种的动机和对 TBE 疫苗属性的偏好。
在奥地利、德国、瑞士和瑞典的普通公众中进行了一项在线调查。参与者年龄在 18 岁及以上，愿意接种疫苗，且居住在上述国家的 TBE 流行地区，或定期前往 TBE 流行地区。在评估 TBE 疫苗属性的重要性之前，参与者被问到他们的一般疫苗知识和接种疫苗的动机，例如疗效、安全性、给药方案和加强剂间隔。此后，参与者在三个具有不同属性组合的假设 TBE 疫苗概况中进行了选择。在假设疗效和安全性相等的情况下，参与者被要求从 12 个屏幕中选择他们首选的概况，作为离散选择联合分析的一部分。使用效用得分来显示每个属性的重要性。按年龄和性别列出了总体调查人群的数据，并使用 t 检验比较平均值。
对于 73%的参与者（n=1003/1379），自我保护是接种疫苗的前三大原因之一。对于超过一半的参与者来说，疾病的严重程度、保护儿童或家人，以及医生/医疗保健专业人员的建议或推荐，也是接种疫苗的前三大原因。大多数（58-69%）参与者同意或强烈同意他们信任医生/医疗保健专业人员在疫苗方面的建议，他们依赖医生/医疗保健专业人员的疫苗知识，并且他们希望医生/医疗保健专业人员就他们或他们的家人应接种哪些疫苗提出建议。疗效和安全性是最重要的独立 TBE 疫苗属性；然而，在包括 3 年、5 年和 10 年加强剂间隔的 TBE 疫苗概况中，在选择首选疫苗概况时，10 年加强剂间隔是最具影响力的属性水平（效用得分：0.58[标准误差：0.01]）。在年龄和性别亚组中观察到动机和偏好的差异。
对医生/医疗保健专业人员的高度依赖强调了医生/医疗保健专业人员在影响疫苗决策方面的关键作用。加强剂间隔是选择 TBE 疫苗概况时的最大驱动因素，对 10 年加强剂间隔的偏好最强。这些发现可用于为 TBE 疫苗接种建议提供信息，并为 TBE 疫苗的进一步发展提供信息。
