Department of Clinical Laboratory, Women and Children's Hospital of Chongqing Medical University, Chongqing, 401174, China.
Department of Clinical Laboratory, Chongqing Health Center for Women and Children, 120 Longshan Road, Chongqing, 401174, China.
Sci Rep. 2024 Oct 14;14(1):23973. doi: 10.1038/s41598-024-74588-x.
Human papillomavirus (HPV) infection is widespread. The regional differences in infection rates and dominant HPV types are a significant aspect of the virus's epidemiological characteristics. In China, these differences are further influenced by the country's diverse ethnic composition, as well as varying economic and cultural conditions across regions. Additionally, factors such as population migration contribute to the exacerbation of these regional disparities in HPV infection rates.
We conducted an analysis of the current prevalence of HPV among 108,863 patients in Chongqing from 2017 to 2022, along with an investigation into the interaction between HPV and vaginal microbiota. Additionally, we explored the relationship between HPV clearance time and disease outcomes.
Our findings revealed an overall HPV positive rate of 30.14% (32,813/108,863) in Chongqing, China. The top five HPV positive rates were as follows: HPV52 (7.78%), HPV16 (5.85%), HPV58 (4.41%), HPV53 (3.17%), and HPV39 (2.47%). The age-related trend of HPV infection exhibited a bimodal curve. Importantly, the positive rate of high-risk HPV (BV: 24.74%, AV: 24.38%, VVC: 18.19%, TV: 22.81%) was significantly higher than those in the control group (all P<0.05). Follow-up for 4 years, we observed an overall clearance rate of HPV at 92.20%, with a median clearance time of 13 (1-61) months.
These findings hold significant implications for the Chinese government in evaluating the prevalence of HPV in the Chongqing region and formulating effective HPV prevention strategies. Moreover, these findings could contribute to the enhancement of public health initiatives related to HPV in the region.
人乳头瘤病毒（HPV）感染广泛存在。感染率和优势 HPV 型别的地区差异是该病毒流行病学特征的一个重要方面。在中国，这些差异还受到该国多样化的民族构成以及不同地区经济和文化条件的影响。此外，人口迁移等因素加剧了 HPV 感染率的地区差异。
我们分析了 2017 年至 2022 年重庆 108863 例患者 HPV 的当前流行情况，并调查了 HPV 与阴道微生物群之间的相互作用。此外，我们还探讨了 HPV 清除时间与疾病结局之间的关系。
我们的研究结果显示，中国重庆 HPV 总阳性率为 30.14%（32813/108863）。HPV 阳性率最高的前 5 种 HPV 型别依次为：HPV52（7.78%）、HPV16（5.85%）、HPV58（4.41%）、HPV53（3.17%）和 HPV39（2.47%）。HPV 感染的年龄相关趋势呈双峰曲线。重要的是，高危型 HPV 的阳性率（BV：24.74%，AV：24.38%，VVC：18.19%，TV：22.81%）明显高于对照组（均 P<0.05）。随访 4 年，HPV 总清除率为 92.20%，中位清除时间为 13（1-61）个月。
这些发现对中国政府评估重庆地区 HPV 的流行情况以及制定有效的 HPV 预防策略具有重要意义。此外，这些发现还可以为该地区增强与 HPV 相关的公共卫生计划提供参考。
