中国武汉 105679 名女性人乳头瘤病毒感染的流行病学研究。

Epidemiological study of human papillomavirus infection in 105,679 women in Wuhan, China.

机构信息

Department of Laboratory Medicine, Wuhan Children's Hospital, Wuhan Maternal and Child Healthcare Hospital, Tongji Medical College，Huazhong University of Science & Technology, Wuhan, PR China.

Information Department, Wuhan Children's Hospital, Wuhan Maternal and Child Healthcare Hospital, Tongji Medical College，Huazhong University of Science & Technology, Wuhan, PR China.

出版信息

BMC Infect Dis. 2024 Oct 7;24(1):1111. doi: 10.1186/s12879-024-10011-0.

DOI:10.1186/s12879-024-10011-0

PMID:39375610

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11457396/

Abstract

BACKGROUND

Quality assessment of the prevalence and distribution of human papillomavirus (HPV) genotypes could support additional targeted HPV vaccinations. However, the characteristics of HPV infection in Wuhan city are limited in the past decade. We aimed to assess the epidemiology of HPV infection among women and provide a reference for the prevention and treatment of cervical cancer in this region.

METHODS

A retrospective study employing 105,679 women attending Wuhan Medical and Health Center for Women and Children for cervical cancer screening from January 2015 to December 2022 was conducted. The HPV genotype was detected by polymerase chain reaction (PCR) and diversion hybridization. The overall incidence and age-specific type distribution of HPV infection and the relationship between HPV infection and cervical cytology were analyzed.

RESULTS

The overall HPV infection rate was 16.87% in Wuhan city, and the prevalence rates of high-risk, low-risk and mixed high- and low-risk HPV infections were 13.64%, 1.77% and 1.46%, respectively. The five most prevalent genotypes were HPV52 (4.24%), HPV58 (2.42%), HPV16 (2.34%), HPV53 (1.87%), and HPV39 (1.66%). The prevalence of HPV in women exhibited a "two-peak" pattern, the peaks of which were observed in the < 21 years group (37.4%) and the 61-65 years group (41.72%). Logistic regression analysis revealed no significant difference in the rate of high-grade lesion positivity between single and multiple high-risk HPV infections. Among patients with a high-grade squamous intraepithelial lesion+ (HSIL+) ThinPrep cytologic test (TCT) diagnosis, HPV58 was the most common type, followed by HPV52, HPV16, HPV39 and HPV53.

CONCLUSIONS

HPV types 52, 58, 16, 53, and 39 were the most common types in the general female population in Wuhan, and the prevalence of HPV infection varied among different age groups. This study provides a comprehensive overview of the epidemiological characteristics of HPV infection in women, which could support the development of targeted prevention and control strategies for cervical cancer in the region.

摘要

背景

评估人乳头瘤病毒（HPV）基因型的流行率和分布情况可支持对 HPV 进行额外的靶向疫苗接种。然而，过去十年中，武汉市 HPV 感染的特征有限。我们旨在评估该地区女性 HPV 感染的流行病学，并为该地区宫颈癌的预防和治疗提供参考。

方法

采用回顾性研究方法，对 2015 年 1 月至 2022 年 12 月期间在武汉市妇幼保健院因宫颈癌筛查而就诊的 105679 名女性进行研究。采用聚合酶链反应（PCR）和分流杂交技术检测 HPV 基因型。分析 HPV 感染的总发生率和年龄特异性分布类型，以及 HPV 感染与宫颈细胞学之间的关系。

结果

武汉市 HPV 总感染率为 16.87%，高危型、低危型和高低危混合型 HPV 感染的流行率分别为 13.64%、1.77%和 1.46%。最常见的五种基因型为 HPV52（4.24%）、HPV58（2.42%）、HPV16（2.34%）、HPV53（1.87%）和 HPV39（1.66%）。女性 HPV 感染呈“双峰”模式，两个高峰分别出现在<21 岁组（37.4%）和 61-65 岁组（41.72%）。Logistic 回归分析显示，单一高危型 HPV 感染和多重高危型 HPV 感染的高级别病变阳性率无显著差异。在高分化鳞状上皮内病变+（HSIL+）液基细胞学检查（TCT）诊断的患者中，HPV58 是最常见的类型，其次是 HPV52、HPV16、HPV39 和 HPV53。