Le Ngoan Tran, Pham Yen Thi-Hai, Lu Y-Thanh, Le Linh Thuy, Huynh Nhi Yen Ngoc, Dao Hang Viet, Nguyen Dai Duc, Demanelis Kathryn, Ha Toan H, Kuchipudi Suresh V, Luu Hung N
Institute of Research and Development, Duy Tan University, Da Nang, Vietnam.
Department of Occupational Health, Institute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi, Vietnam.
Nutr Cancer. 2025;77(2):252-264. doi: 10.1080/01635581.2024.2415143. Epub 2024 Oct 13.
There is inconclusive evidence on the role of dietary intake of vitamin B in cancer. We evaluated the association between vitamin B intake and cancer risk in a hospital-based case-control study, comprising 3,758 cancer cases and 2,995 controls in Vietnam. Vitamin B intake was derived from the validated food frequency questionnaire. Unconditional logistic regression model was used to calculate the odds ratios (ORs), and respective 95% confidence intervals (CIs) for the association between vitamin B and cancer risk. There was a U-shaped association between vitamin B intake and overall risk of cancer. Individuals with intakes lower than the median intake had a 6% (OR = 1.06, 95% CI: 0.86-1.31)-107% (OR = 2.07, 95% CI: 1.58-2.71), increased risk of cancer (<0.001), whereas those with higher intakes than the median intake had a 20% (OR = 1.20, 95% CI: 0.97-1.48)-52% (OR = 1.52, 95% CI: 1.22-1.89) increased risk of cancer (<0.04). The excess risk of cancer associated with low intakes of vitamin B was observed among esophageal, lung, and breast cancer patients, whereas with high intakes of vitamin B among gastric cancer patients. In summary, a U-shaped association between vitamin B intake and increased cancer risk was observed in the Vietnamese population.
关于饮食中维生素B摄入量在癌症中的作用，证据尚无定论。我们在一项基于医院的病例对照研究中评估了维生素B摄入量与癌症风险之间的关联，该研究纳入了越南的3758例癌症病例和2995例对照。维生素B摄入量来自经过验证的食物频率问卷。使用无条件逻辑回归模型计算比值比（OR）以及维生素B与癌症风险之间关联的相应95%置信区间（CI）。维生素B摄入量与总体癌症风险之间呈U形关联。摄入量低于中位数的个体患癌风险增加6%（OR = 1.06，95% CI：0.86 - 1.31）至107%（OR = 2.07，95% CI：1.58 - 2.71）（<0.001），而摄入量高于中位数的个体患癌风险增加20%（OR = 1.20，95% CI：0.97 - 1.48）至52%（OR = 1.52，95% CI：1.22 - 1.89）（<0.04）。在食管癌、肺癌和乳腺癌患者中观察到维生素B摄入量低与癌症额外风险相关，而在胃癌患者中观察到维生素B摄入量高与癌症额外风险相关。总之，在越南人群中观察到维生素B摄入量与癌症风险增加之间呈U形关联。
