Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou510080, People's Republic of China.
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou510080, People's Republic of China.
Br J Nutr. 2020 Jun 14;123(11):1277-1289. doi: 10.1017/S0007114520000501. Epub 2020 Feb 14.
B vitamins (including folate, vitamin B2, vitamin B6 and vitamin B12) and methionine are essential for methylation reactions, nucleotide synthesis, DNA stability and DNA repair. However, epidemiological evidence among Chinese populations is limited. The objective of this study was to evaluate B vitamins and methionine in relation to colorectal cancer risk in a Chinese population. A case-control study was conducted from July 2010 to April 2019. A total of 2502 patients with colorectal cancer were recruited along with 2538 age- (5-year interval) and sex-matched controls. Dietary data were collected using a validated FFQ. Multivariable logistic regression was used to assess OR and 95 % CI. The intake of folate, vitamin B2, vitamin B6 and vitamin B12 was inversely associated with colorectal cancer risk. The multivariable OR for the highest quartile v. the lowest quartile were 0·62 (95 % CI 0·51, 0·74; Ptrend < 0·001) for folate, 0·46 (95 % CI 0·38, 0·55; Ptrend < 0·001) for vitamin B2, 0·55 (95 % CI 0·46, 0·76; Ptrend < 0·001) for vitamin B6 and 0·72 (95 % CI 0·60, 0·86; Ptrend < 0·001) for vitamin B12. No statistically significant association was found between methionine intake and colorectal cancer risk. Stratified analysis by sex showed that the inverse associations between vitamin B12 and methionine intake and colorectal cancer risk were found only among women. This study indicated that higher intake of folate, vitamin B2, vitamin B6 and vitamin B12 was associated with decreased risk of colorectal cancer in a Chinese population.
B 族维生素（包括叶酸、维生素 B2、维生素 B6 和维生素 B12）和蛋氨酸是甲基化反应、核苷酸合成、DNA 稳定性和 DNA 修复所必需的。然而，中国人群的流行病学证据有限。本研究旨在评估 B 族维生素和蛋氨酸与中国人群结直肠癌风险的关系。本病例对照研究于 2010 年 7 月至 2019 年 4 月进行。共招募了 2502 例结直肠癌患者和 2538 例年龄（每 5 年间隔）和性别匹配的对照。采用经过验证的 FFQ 收集膳食数据。采用多变量 logistic 回归评估 OR 和 95%CI。叶酸、维生素 B2、维生素 B6 和维生素 B12 的摄入量与结直肠癌风险呈负相关。最高四分位 v. 最低四分位的多变量 OR 分别为叶酸 0·62（95%CI 0·51，0·74；Ptrend < 0·001）、维生素 B2 0·46（95%CI 0·38，0·55；Ptrend < 0·001）、维生素 B6 0·55（95%CI 0·46，0·76；Ptrend < 0·001）和维生素 B12 0·72（95%CI 0·60，0·86；Ptrend < 0·001）。蛋氨酸摄入量与结直肠癌风险之间无统计学显著关联。按性别分层分析显示，仅在女性中观察到维生素 B12 和蛋氨酸摄入与结直肠癌风险之间的负相关。本研究表明，在中国人群中，较高的叶酸、维生素 B2、维生素 B6 和维生素 B12 摄入量与结直肠癌风险降低相关。
