Ross D L, Swaiman K F, Torres F, Hansen J
Division of Pediatric Neurology, University of Minnesota Medical School, Minneapolis.
Pediatr Neurol. 1985 Mar-Apr;1(2):104-8. doi: 10.1016/0887-8994(85)90045-1.
Early changes in blood chemistry and the electroencephalogram were monitored during the first three hours after initiating the medium chain triglyceride (MCT) diet in nine children with intractable atypical absence seizures. Serum glucose, insulin, triglycerides, cholesterol, free fatty acids, ketone bodies concentrations, and venous pH were assayed before and at timed intervals after MCT oil was administered orally. The concentration of serum ketones rose progressively over three hours, beta-hydroxybutyrate proportionately higher than acetoacetate. A statistically significant decrease in the group mean number of epileptiform discharges occurred following MCT therapy. Seizure frequency decreased by more than 50 percent in two-thirds of the children during the 10 week treatment period.
在9名患有顽固性非典型失神发作的儿童开始食用中链甘油三酯（MCT）饮食后的前三个小时，监测其血液化学和脑电图的早期变化。在口服MCT油之前和之后的定时间隔测定血清葡萄糖、胰岛素、甘油三酯、胆固醇、游离脂肪酸、酮体浓度和静脉血pH值。血清酮浓度在三个小时内逐渐升高，β-羟基丁酸酯的升高比例高于乙酰乙酸。MCT治疗后，癫痫样放电的组平均数有统计学意义的下降。在10周的治疗期内，三分之二的儿童癫痫发作频率降低了50%以上。
