Tekin Zeynep Zehra, Pamukcu Hilal Erken, Kayihan Serdar, Ucan Bekir, Bostan Hayri, Gul Umran, Duger Hakan, Hepsen Sema, Cakal Erman, Akdag Seyit Ibrahim, Kizilgul Muhammed
Etlik City Hospital, Department of Internal Medicine, Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle, Ankara, Turkey.
Sanliurfa Training and Research Hospital, Depeartment of Internal Medicine, Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle, Turkey.
Heliyon. 2024 Sep 19;10(19):e38033. doi: 10.1016/j.heliyon.2024.e38033. eCollection 2024 Oct 15.
The risk of death is increased in acromegaly patients compared to the general population, and cardiovascular system-related complications are among the risk factors decreasing life expectancy. The Tp-e interval, which is the distance between the point where the T-wave peaks and ends on electrocardiography (ECG), shows ventricular rapolarization and, together with the Tp-e/QT and Tp-e/QTc ratios, these are relatively new tools that predict ventricular arrhythmia. We aimed to evaluate the ECG of acromegaly patients at the time of diagnosis and compare the results with current ECG findings.
The study included 103 acromegaly patients and 81 control subjects. Of the 103 patients, 41 patients had only baseline ECG, 23 patients had only current ECG and 39 patients had both baseline and current ECGs. Heart rate, QT interval and corrected QT (QTc) interval, Tp-e, Tp-e/QT, Tp-e/QTc values on the ECGs were measured by a cardiologist.
In the acromegaly patients with both baseline and current ECGs, heart rate, QRS duration, Tp-e, and Tp-e/QTc ratio were decreased. The decrease in these arrhythmia parameters was similar in active and remission patients. Compared to the control group, in acromegaly patients with only baseline ECG, heart rate, QTc interval, Tp-e, Tp-e/QT, and Tp-e/QTc were decreased.
Ventricular arrhythmia parameters improve with treatment in patients with acromegaly. The decrease in ventricular arrhythmia parameters was similar in active and remission patients, which can be explained by the significant decrease in IGF-1 levels compared to the time of diagnosis, even in patients with active disease.
与普通人群相比，肢端肥大症患者的死亡风险增加，心血管系统相关并发症是降低预期寿命的风险因素之一。心电图（ECG）上T波峰点与终点之间的距离即Tp-e间期，显示心室复极，并且与Tp-e/QT和Tp-e/QTc比值一起，是预测室性心律失常的相对较新的工具。我们旨在评估肢端肥大症患者诊断时的心电图，并将结果与当前的心电图检查结果进行比较。
该研究纳入了103例肢端肥大症患者和81例对照受试者。在103例患者中，41例患者仅有基线心电图，23例患者仅有当前心电图，39例患者同时有基线和当前心电图。心电图上的心率、QT间期和校正QT（QTc）间期、Tp-e、Tp-e/QT、Tp-e/QTc值由一名心脏病专家测量。
在同时有基线和当前心电图的肢端肥大症患者中，心率、QRS时限、Tp-e和Tp-e/QTc比值降低。这些心律失常参数的降低在活动期和缓解期患者中相似。与对照组相比，在仅有基线心电图的肢端肥大症患者中，心率、QTc间期、Tp-e、Tp-e/QT和Tp-e/QTc降低。
肢端肥大症患者经治疗后室性心律失常参数有所改善。活动期和缓解期患者室性心律失常参数的降低相似，这可以用与诊断时相比IGF-1水平显著降低来解释，即使是患有活动期疾病的患者。
