Md Fadilah Nur Izzah, Shahabudin Nurul Aqilah, Mohd Razif Raniya Adiba, Sanyal Arka, Ghosh Anushikha, Baharin Khairul Idzwan, Ahmad Haslina, Maarof Manira, Motta Antonella, Fauzi Mh Busra
Department of Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia.
Advance Bioactive Materials-Cells UKM Research Group, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia.
J Tissue Eng. 2024 Sep 29;15:20417314241280359. doi: 10.1177/20417314241280359. eCollection 2024 Jan-Dec.
Short sequences of amino acids called peptides have a wide range of biological functions and the potential to treat a number of diseases. Bioactive peptides can be derived from different sources, including marine organisms, and synthetic design, making them versatile candidates for production of therapeutic agents. Their therapeutic effects span across areas such as antimicrobial activity, cells proliferation and migration, synthesis of collagen, and more. This current review explores the fascinating realm of bioactive peptides as promising therapeutic agents for skin wound healing. This review focuses on the multifaceted biological effects of specific peptides, shedding light on their potential to revolutionize the field of dermatology and regenerative medicine. It delves into how these peptides stimulate collagen synthesis, inhibit inflammation, and accelerate tissue regeneration, ultimately contributing to the effective repair of skin wounds. The findings underscore the significant role several types of bioactive peptides can play in enhancing wound healing processes and offer promising insights for improving the quality of life for individuals with skin injuries and dermatological conditions. The versatility of peptides allows for the development of tailored treatments catering to specific wound types and patient needs. As continuing to delve deeper into the realm of bioactive peptides, there is immense potential for further exploration and innovation. Future endeavors may involve the optimization of peptide formulations, elucidation of underlying molecular and cellular mechanisms.
被称为肽的短氨基酸序列具有广泛的生物学功能以及治疗多种疾病的潜力。生物活性肽可以来源于不同的来源,包括海洋生物,以及通过合成设计获得,这使得它们成为生产治疗剂的通用候选物。它们的治疗作用涵盖抗菌活性、细胞增殖与迁移、胶原蛋白合成等多个领域。本综述探讨了生物活性肽作为皮肤伤口愈合有前景的治疗剂这一迷人领域。本综述聚焦于特定肽的多方面生物学效应,揭示它们在皮肤病学和再生医学领域引发变革的潜力。它深入研究这些肽如何刺激胶原蛋白合成、抑制炎症以及加速组织再生,最终促进皮肤伤口的有效修复。研究结果强调了几种类型的生物活性肽在增强伤口愈合过程中可以发挥的重要作用,并为改善皮肤损伤和皮肤病患者的生活质量提供了有前景的见解。肽的多功能性使得能够开发针对特定伤口类型和患者需求的定制治疗方法。随着继续深入生物活性肽领域,进一步探索和创新具有巨大潜力。未来的努力可能包括优化肽制剂、阐明潜在的分子和细胞机制。