Sanyal Arka, Ghosh Anushikha, Roy Chandrashish, Mazumder Ishanee, Marrazzo Pasquale
School of Biotechnology, KIIT Deemed University, Bhubaneswar 751024, India.
Department of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy.
J Funct Biomater. 2023 Jul 4;14(7):352. doi: 10.3390/jfb14070352.
The field of biomedical engineering highly demands technological improvements to allow the successful engraftment of biomaterials requested for healing damaged host tissues, tissue regeneration, and drug delivery. Polymeric materials, particularly natural polymers, are one of the primary suitable materials employed and functionalized to enhance their biocompatibility and thus confer advantageous features after graft implantation. Incorporating bioactive substances from nature is a good technique for expanding or increasing the functionality of biomaterial scaffolds, which may additionally encourage tissue healing. Our ecosystem provides natural resources, like honeybee products, comprising a rich blend of phytochemicals with interesting bioactive properties, which, when functionally coupled with biomedical biomaterials, result in the biomaterial exhibiting anti-inflammatory, antimicrobial, and antioxidant effects. Bee pollen is a sustainable product recently discovered as a new functionalizing agent for biomaterials. This review aims to articulate the general idea of using honeybee products for biomaterial engineering, mainly focusing on describing recent literature on experimental studies on biomaterials functionalized with bee pollen. We have also described the underlying mechanism of the bioactive attributes of bee pollen and shared our perspective on how future biomedical research will benefit from the fabrication of such functionalized biomaterials.
生物医学工程领域迫切需要技术改进，以实现用于修复受损宿主组织、组织再生和药物递送的生物材料的成功植入。聚合物材料，特别是天然聚合物，是主要使用的合适材料之一，并经过功能化处理以提高其生物相容性，从而在移植后赋予其有利特性。掺入天然生物活性物质是扩展或增加生物材料支架功能的良好技术，这还可以促进组织愈合。我们的生态系统提供自然资源，如蜜蜂产品，其中含有丰富的具有有趣生物活性的植物化学物质，当与生物医学生物材料功能耦合时，会使生物材料表现出抗炎、抗菌和抗氧化作用。蜂花粉是最近被发现可作为生物材料新功能化剂的可持续产品。本综述旨在阐明将蜜蜂产品用于生物材料工程的总体思路，主要侧重于描述近期关于用蜂花粉功能化生物材料的实验研究的文献。我们还描述了蜂花粉生物活性属性的潜在机制，并分享了我们对于未来生物医学研究将如何从这类功能化生物材料的制造中受益的观点。
