Hidig Sakarie Mustafe
Department of Hepatobiliary and Pancreatic Surgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang Province, 322000, PR. China.
Niger Med J. 2024 Sep 26;65(4):387-397. doi: 10.60787/nmj-v65i3-376. eCollection 2024 Jul-Aug.
This comprehensive literature review is to summarize the most recent findings regarding the causes, diagnosis, and treatments of pancreatic cancer and to encourage additional investigation into this under-researched malignant tumor. Pancreatic cancer is a significant public health issue in China, with annual mortality rates almost equal to incidence rates. The disease is more prevalent in rural areas and has a poor prognosis. The data was collected from the following databases: Pub Med, Cross ref, Science Direct, Scopus, and Google Scholar we reviewed published articles from 2018 to 2023 on the annual incidence of pancreatic cancer in China is 5.1%, with only 5-7% of patients completely cured. The prognosis is extremely poor, with a 1-year survival rate of 8% and a 5-year survival rate of 3%. Pancreatic cancer has no specific clinical manifestations or tumor markers, and its characteristics are not typical of high-risk factors including smoking, alcohol, chronic pancreatitis, abnormal microorganism metabolism, blood type, and glucose and lipid levels. For increased detection and survival rates, pancreatic cancer must be diagnosed as early as possible. However, the low specificity of tumor markers calls for more study. Future treatment strategies could include immunotherapy and a microbiology-free system, and it's anticipated that they'll offer intriguing clinical applications for extending patients' lives with pancreatic cancer. Finally, we suggest measures to improve the health outcomes of pancreatic cancer patients in China.
这篇综合性文献综述旨在总结胰腺癌病因、诊断和治疗方面的最新研究成果,并鼓励对这种研究不足的恶性肿瘤展开更多调查。在中国,胰腺癌是一个重大的公共卫生问题,其年死亡率几乎与发病率相当。该疾病在农村地区更为普遍,且预后较差。数据收集自以下数据库:PubMed、Cross ref、ScienceDirect、Scopus和谷歌学术。我们查阅了2018年至2023年发表的关于中国胰腺癌年发病率的文章,其发病率为5.1%,仅有5%至7%的患者能完全治愈。预后极差,1年生存率为8%,5年生存率为3%。胰腺癌没有特定的临床表现或肿瘤标志物,其特征也不典型于包括吸烟、饮酒、慢性胰腺炎、微生物代谢异常、血型以及血糖和血脂水平等高危因素。为提高检出率和生存率,必须尽早诊断胰腺癌。然而,肿瘤标志物的低特异性需要更多研究。未来的治疗策略可能包括免疫疗法和无菌系统,预计它们将为延长胰腺癌患者生命提供有趣的临床应用。最后,我们提出改善中国胰腺癌患者健康结局的措施。