Zhang Boxun, Zhou Lijuan, Chen Keyu, Fang Xinyi, Li Qingwei, Gao Zezheng, Lian Fengmei, Li Min, Tian Jiaxing, Zhao Linhua, Tong Xiaolin
Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053 China.
Graduate College, Beijing University of Chinese Medicine, Beijing, 100029 China.
Phenomics. 2024 Sep 2;4(3):257-268. doi: 10.1007/s43657-023-00146-6. eCollection 2024 Jun.
With thousands of years of application history, traditional Chinese medicine (TCM) has unique advantages in the prevention of various chronic diseases, and in recent years, the development of TCM has presented a situation where opportunities and challenges coexist. Phenomics is an emerging area of life science research, which has numerous similarities to the cognitive perspective of TCM. Thus, how to carry out the interdisciplinary research between TCM and phenomics deserves in-depth discussion. Diabetes is one of the most common chronic non-communicable diseases around the world, and TCM plays an important role in all stages of diabetes treatment, but the molecular mechanisms are difficult to elucidate. Phenomics research can not only reveal the hidden scientific connotations of TCM, but also provide a bridge for the confluence and complementary between TCM and Western medicine. Facing the challenges of the TCM phenomics research, we suggest applying the State-target theory (STT) to overall plan relevant researches, namely, focusing on the disease development, change trends, and core targets of each stage, and to deepen the understanding of TCM disease phenotypes and the therapeutic mechanisms of herbal medicine.
The online version contains supplementary material available at 10.1007/s43657-023-00146-6.
中医有着数千年的应用历史，在预防各类慢性病方面具有独特优势，近年来，中医发展呈现出机遇与挑战并存的局面。表型组学是生命科学研究的一个新兴领域，与中医的认知视角有诸多相似之处。因此，如何开展中医与表型组学的跨学科研究值得深入探讨。糖尿病是全球最常见的慢性非传染性疾病之一，中医在糖尿病治疗的各个阶段都发挥着重要作用，但其分子机制难以阐明。表型组学研究不仅可以揭示中医隐藏的科学内涵，还能为中医与西医的融合互补搭建桥梁。面对中医表型组学研究的挑战，我们建议应用国家目标理论（STT）统筹相关研究，即聚焦疾病各阶段的发展、变化趋势及核心靶点，以深化对中医疾病表型及中药治疗机制的认识。
网络版包含可在10.1007/s43657-023-00146-6获取的补充材料。
