Xu Yi, Wang Yuheng, Mei Shuchong, Hu Jialing, Wu Lidong, Xu Luyang, Bao Lijie, Fang Xiaowei
Department of Emergency Medicine, Jiangxi Medical College, The Second Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, China.
Jiangxi Medical College, The Second Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, China.
Front Pain Res (Lausanne). 2024 Sep 27;5:1452389. doi: 10.3389/fpain.2024.1452389. eCollection 2024.
Pain is a common symptom of many clinical diseases; it adversely affects patients' physical and mental health, reduces their quality of life, and heavily burdens patients and society. Pain treatment is one of the most difficult problems today. There is an urgent need to explore the potential factors involved in the pathogenesis of pain to improve its diagnosis and treatment rate. 1/2, a newly identified mechanosensitive ion channel opens in response to mechanical stimuli and plays a critical role in regulating pain-related diseases. Inhibition or downregulation of 1/2 alleviates disease-induced pain. Therefore, in this study, we comprehensively discussed the biology of this gene, focusing on its potential relevance in pain-related diseases, and explored the pharmacological effects of drugs using this gene for the treatment of pain.
疼痛是许多临床疾病的常见症状；它对患者的身心健康产生不利影响，降低他们的生活质量，并给患者和社会带来沉重负担。疼痛治疗是当今最棘手的问题之一。迫切需要探索疼痛发病机制中涉及的潜在因素，以提高其诊断和治疗率。1/2是一种新发现的机械敏感离子通道，它对机械刺激作出反应而开启，并在调节疼痛相关疾病中起关键作用。抑制或下调1/2可减轻疾病引起的疼痛。因此，在本研究中，我们全面讨论了该基因的生物学特性，重点关注其在疼痛相关疾病中的潜在相关性，并探索了使用该基因治疗疼痛的药物的药理作用。
