Das Kaustuv, Sen Jayshree, Borode Aishwarya S
Anaesthesiology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2024 Sep 12;16(9):e69261. doi: 10.7759/cureus.69261. eCollection 2024 Sep.
Ketamine, a dissociative anesthetic primarily recognized for its antagonism of N-methyl-D-aspartate (NMDA) receptors, has gained significant attention for its rapid antidepressant effects and potential in treating mood disorders. However, recent research indicates that ketamine's influence extends beyond NMDA receptor inhibition, affecting α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and sensory processing. This review delves into ketamine's role in enhancing AMPA receptor function and its implications for sensory processing within the somatosensory cortex. AMPA receptors, essential for fast excitatory neurotransmission and synaptic plasticity, play a key role in sensory perception and integration. By examining preclinical and clinical studies, this review sheds light on how ketamine's modulation of AMPA receptors may improve sensory processing and contribute to its therapeutic effects. Additionally, the review explores the potential for ketamine-based therapies to treat sensory processing disorders and refine current treatment strategies. A deeper understanding of ketamine's complex effects on AMPA receptors and sensory processing could provide valuable insights for developing targeted interventions and advancing clinical applications.
氯胺酮是一种主要因其对N-甲基-D-天冬氨酸（NMDA）受体的拮抗作用而被认可的解离性麻醉剂，因其快速的抗抑郁作用和治疗情绪障碍的潜力而备受关注。然而，最近的研究表明，氯胺酮的影响不仅限于抑制NMDA受体，还会影响α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）受体和感觉处理。本综述深入探讨氯胺酮在增强AMPA受体功能中的作用及其对体感皮层内感觉处理的影响。AMPA受体对快速兴奋性神经传递和突触可塑性至关重要，在感觉感知和整合中起关键作用。通过研究临床前和临床研究，本综述阐明了氯胺酮对AMPA受体的调节如何改善感觉处理并促进其治疗效果。此外，该综述探讨了基于氯胺酮的疗法治疗感觉处理障碍和完善当前治疗策略的潜力。对氯胺酮对AMPA受体和感觉处理的复杂影响有更深入的了解，可为开发针对性干预措施和推进临床应用提供有价值的见解。
