Scott Adam, Khoruts Alexander, Freeman Martin L, Beilman Greg, Ramanathan Karthik, Bellin Melena D, Trikudanathan Guru
University of Minnesota Medical School, Minneapolis, MN.
University of Minnesota Medical Center, Minneapolis, MN.
ACG Case Rep J. 2024 Oct 11;11(10):e01527. doi: 10.14309/crj.0000000000001527. eCollection 2024 Oct.
Alterations in the gut microbiome have been implicated in various pathologies. Fecal microbiota transplantation (FMT) has been offered as a novel treatment for conditions implicated in the disruption of the gut-microbiota axis. This case report details the successful treatment of recurrent nonobstructive cholangitis following a single FMT application in a patient who had previously undergone a hepatobiliary tract surgical diversion. Cholangitis was suspected secondary to reflux of an altered microbiome into the surgically reanastomosed biliary tract, and FMT was justified based on the history of recurrent infections. This case supports the further evaluation of the utility of FMT as one potential treatment of post hepatobiliary surgical diversion cholangitis.
肠道微生物群的改变与多种疾病有关。粪便微生物群移植（FMT）已被作为一种针对与肠道微生物群轴破坏相关病症的新型治疗方法。本病例报告详细介绍了一名先前接受过肝胆管手术改道的患者在单次FMT治疗后复发性非梗阻性胆管炎的成功治疗情况。怀疑胆管炎是由于改变的微生物群反流至手术重新吻合的胆道所致，基于反复感染的病史，FMT是合理的。本病例支持进一步评估FMT作为肝胆管手术后改道胆管炎一种潜在治疗方法的效用。
