Laboratory of Chromosome and Cell Biology, The Rockefeller University, New York, NY, USA.
J Cell Biol. 2024 Nov 4;223(11). doi: 10.1083/jcb.202409044. Epub 2024 Oct 14.
Chromosomes undergo dramatic compaction during mitosis, but accurately measuring their volume has been challenging. Employing serial block face scanning electron microscopy, Cisneros-Soberanis et al. (https://doi.org/10.1083/jcb.202403165) report that mitotic chromosomes compact to a nucleosome concentration of ∼760 µM.
染色体在有丝分裂过程中经历剧烈的紧缩，但准确测量其体积一直具有挑战性。Cisneros-Soberanis 等人采用连续块面扫描电子显微镜技术（https://doi.org/10.1083/jcb.202403165）报告称，有丝分裂染色体紧缩至核小体浓度约为 760 µM。
