有丝分裂染色体浓缩到什么程度？
How condensed are mitotic chromosomes?
机构信息
Laboratory of Chromosome and Cell Biology, The Rockefeller University, New York, NY, USA.
出版信息
J Cell Biol. 2024 Nov 4;223(11). doi: 10.1083/jcb.202409044. Epub 2024 Oct 14.
Abstract
Chromosomes undergo dramatic compaction during mitosis, but accurately measuring their volume has been challenging. Employing serial block face scanning electron microscopy, Cisneros-Soberanis et al. (https://doi.org/10.1083/jcb.202403165) report that mitotic chromosomes compact to a nucleosome concentration of ∼760 µM.
摘要
染色体在有丝分裂过程中经历剧烈的紧缩，但准确测量其体积一直具有挑战性。Cisneros-Soberanis 等人采用连续块面扫描电子显微镜技术（https://doi.org/10.1083/jcb.202403165）报告称，有丝分裂染色体紧缩至核小体浓度约为 760 µM。
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How condensed are mitotic chromosomes?有丝分裂染色体浓缩到什么程度？
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本文引用的文献
1
Chromosome arm length, and a species-specific determinant, define chromosome arm width.染色体臂长度和物种特异性决定因素决定了染色体臂宽度。
Cell Rep. 2022 Dec 6;41(10):111753. doi: 10.1016/j.celrep.2022.111753.
2
Local nucleosome dynamics facilitate chromatin accessibility in living mammalian cells.局部核小体动力学促进活哺乳动物细胞中的染色质可及性。
Cell Rep. 2012 Dec 27;2(6):1645-56. doi: 10.1016/j.celrep.2012.11.008. Epub 2012 Dec 13.
3
Chromatin structure: does the 30-nm fibre exist in vivo?染色质结构：30nm 纤维是否存在于体内？
Curr Opin Cell Biol. 2010 Jun;22(3):291-7. doi: 10.1016/j.ceb.2010.03.001. Epub 2010 Mar 24.
4
Maximal chromosome compaction occurs by axial shortening in anaphase and depends on Aurora kinase.最大程度的染色体压缩在后期通过轴向缩短发生，并且依赖于极光激酶。
Nat Cell Biol. 2007 Jul;9(7):822-31. doi: 10.1038/ncb1606. Epub 2007 Jun 10.
5
Walther Flemming: pioneer of mitosis research.瓦尔特·弗莱明：有丝分裂研究的先驱。
Nat Rev Mol Cell Biol. 2001 Jan;2(1):72-5. doi: 10.1038/35048077.
6
Polymer models of meiotic and mitotic chromosomes.减数分裂和有丝分裂染色体的聚合物模型。
Mol Biol Cell. 1997 Nov;8(11):2217-31. doi: 10.1091/mbc.8.11.2217.
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