Liu Chaoqun, Ye Xinwu, Chen Minshan
Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang, China.
Suicide Life Threat Behav. 2025 Feb;55(1):e13132. doi: 10.1111/sltb.13132. Epub 2024 Oct 14.
The study aims to investigate the efficacy of sertraline medication plus dialectical behavior therapy (DBT) in reducing nonsuicidal self-injury (NSSI) behavior and depression among adolescents.
Participants were 100 adolescents with depression and NSSI behaviors, 50 of whom received sertraline medication plus DBT and 50 of whom received sertraline medication plus cognitive behavioral therapy (CBT) for 12 weeks.
During 6 months post intervention, 26 (57.8%) participants did not report having engaged in any form of NSSI in the sertraline + DBT group and 15 (32.6%) in the sertraline + CBT group, showing significant difference. The sertraline + DBT group and the sertraline + CBT group exhibited significant difference regarding the proportions of cutting skin and biting self. The scores of anxiety, depression, aggression against self in four modified overt aggression scale categories, and Personal and Social Performance were notably lower in the sertraline + DBT group than those in the sertraline + CBT group at 6 months post intervention.
Sertraline medication plus DBT could decrease NSSI episodes and improve symptoms of anxiety and depression for adolescents, and these changes were comparable to those of CBT. More importantly, DBT was demonstrated better clinical improvements at 6-month follow-up.
本研究旨在探讨舍曲林药物联合辩证行为疗法（DBT）在减少青少年非自杀性自伤（NSSI）行为和抑郁方面的疗效。
100名有抑郁和NSSI行为的青少年参与研究，其中50名接受舍曲林药物联合DBT治疗，50名接受舍曲林药物联合认知行为疗法（CBT）治疗，为期12周。
干预后6个月期间，舍曲林+DBT组有26名（57.8%）参与者未报告有任何形式的NSSI行为，舍曲林+CBT组有15名（32.6%），两组差异显著。舍曲林+DBT组和舍曲林+CBT组在割伤皮肤和咬自己的比例方面存在显著差异。干预后6个月，舍曲林+DBT组在四个改良外显攻击量表类别中的焦虑、抑郁、自我攻击得分以及个人和社会表现得分均显著低于舍曲林+CBT组。
舍曲林药物联合DBT可减少青少年的NSSI发作，改善焦虑和抑郁症状，且这些变化与CBT相当。更重要的是，在6个月随访时，DBT显示出更好的临床改善效果。
