Digestive Disease and Surgery Institute, Cleveland Clinic, Ohio, USA.
Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Clin Transl Med. 2024 Oct;14(10):e70018. doi: 10.1002/ctm2.70018.
Dietary fibres consist of a heterogeneous group of carbohydrate polymers which resist digestion by human gastrointestinal enzymes. Consumption of dietary fibre has been linked with innumerable health benefits encompassing the foundational pillars of metabolic health from obesity to hypertension, dyslipidaemia, and type 2 diabetes mellitus (T2DM), with many of these benefits linked with metabolites produced by the fermentation of fibre by gut microbes [1]. The potential of dietary fibre to provide a safe and effective nonpharmacologic complementary tool with which to combat the evolving consequences of the obesity epidemic has recently garnered tremendous attention in both medical literature and lay media alike. HIGHLIGHTS: Consumption of dietary fibre has been linked with innumerable health benefits encompassing the foundational pillars of metabolic health with many of these benefits linked with metabolites produced by the fermentation of fibre by gut microbes At the present time clinicians are faced with an impossible task in which there is rapidly mounting evidence for dietary fibres advancing metabolic health, but little practical options for healthcare providers other than to simply recommend patients consume more fibre. Benefits of fibre intake may perhaps be maximised in an individual by matching specific fibre consumption with existing microbial functional characteristics If dietary fibres could be demonstrated to act as successful adjuncts to sustain or improve standard of care therapies or even alleviate common gastrointestinal side effects associated with current treatments, they would be an invaluable tool in our metabolic health armamentarium. Neither Dr. Madsen or I have any financial conflicts of interest pertinent to the contents of this manuscript.
膳食纤维由一组异质的碳水化合物聚合物组成，这些聚合物可抵抗人体胃肠道酶的消化。膳食纤维的摄入与无数的健康益处有关，涵盖了从肥胖到高血压、血脂异常和 2 型糖尿病（T2DM）等代谢健康的基础支柱，其中许多益处与肠道微生物发酵纤维产生的代谢物有关[1]。膳食纤维有可能成为一种安全有效的非药物补充工具，用于对抗肥胖流行带来的不断变化的后果，最近在医学文献和大众媒体中都引起了极大的关注。要点：膳食纤维的摄入与无数的健康益处有关，这些益处与肠道微生物发酵纤维产生的代谢物有关目前，临床医生面临着一项不可能完成的任务，即有大量证据表明膳食纤维可以促进代谢健康，但对于医疗保健提供者来说，除了简单地建议患者多摄入纤维外，几乎没有实际的选择。通过将特定的纤维摄入量与现有的微生物功能特征相匹配，个体可能会最大限度地受益于纤维的摄入如果膳食纤维可以被证明作为成功的辅助手段来维持或改善标准的治疗方法，甚至减轻与当前治疗相关的常见胃肠道副作用，那么它们将是我们代谢健康武器库中非常有价值的工具。Madsen 博士和我都没有与本文内容相关的财务利益冲突。
