University of Bern, Institute of Complementary and Integrative Medicine, Fabrikstrasse 8, 3012, Bern, Switzerland.
Biomedical Optics Research Laboratory, Neonatology Research, Department of Neonatology, University Hospital Zurich, University of Zurich, 8091, Zurich, Switzerland.
Sci Rep. 2021 May 6;11(1):9654. doi: 10.1038/s41598-021-88059-0.
Light evokes robust visual and nonvisual physiological and psychological effects in humans, such as emotional and behavioral responses, as well as changes in cognitive brain activity and performance. The aim of this study was to investigate how colored light exposure (CLE) and a verbal fluency task (VFT) interact and affect cerebral hemodynamics, oxygenation, and systemic physiology as determined by systemic physiology augmented functional near-infrared spectroscopy (SPA-fNIRS). 32 healthy adults (17 female, 15 male, age: 25.5 ± 4.3 years) were exposed to blue and red light for 9 min while performing a VFT. Before and after the CLE, subjects were in darkness. We found that this long-term CLE-VFT paradigm elicited distinct changes in the prefrontal cortex and in most systemic physiological parameters. The subjects' performance depended significantly on the type of VFT and the sex of the subject. Compared to red light, blue evoked stronger responses in cerebral hemodynamics and oxygenation in the visual cortex. Color-dependent changes were evident in the recovery phase of several systemic physiological parameters. This study showed that the CLE has effects that endure at least 15 min after cessation of the CLE. This underlines the importance of considering the persistent influence of colored light on brain function, cognition, and systemic physiology in everyday life.
光会在人类身上引起强烈的视觉和非视觉生理和心理效应，例如情绪和行为反应，以及认知脑活动和表现的变化。本研究旨在探讨彩色光暴露 (CLE) 和口头流畅性任务 (VFT) 如何相互作用并影响大脑血液动力学、氧合和全身生理学，这是通过全身生理学增强近红外光谱 (SPA-fNIRS) 确定的。32 名健康成年人（17 名女性，15 名男性，年龄：25.5 ± 4.3 岁）在执行 VFT 时暴露于蓝色和红色光 9 分钟。在 CLE 之前和之后，受试者处于黑暗中。我们发现，这种长期的 CLE-VFT 范式在前额叶皮层和大多数全身生理参数中引起了明显的变化。受试者的表现明显取决于 VFT 的类型和受试者的性别。与红光相比，蓝光在视觉皮层中引起更强的大脑血液动力学和氧合反应。几种全身生理参数的恢复阶段出现了与颜色相关的变化。这项研究表明，CLE 在停止 CLE 后至少 15 分钟仍有效果。这强调了在日常生活中考虑彩色光对大脑功能、认知和全身生理学的持续影响的重要性。
