Department of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama, Shiga, Japan.
Faculty of Health Sciences, Kochi Gakuen University, Kochi, Japan.
Adv Exp Med Biol. 2024;1463:191-194. doi: 10.1007/978-3-031-67458-7_32.
Sleep apnea syndrome (SAS) is associated with cardiopulmonary and dental nasopharyngeal diseases. The blood oxygen saturation (SpO) detected using pulse oximetry is a diagnostic screening method for SAS. SAS severity is assessed using the oxygen desaturation index (ODI), which measures the number of times the SpO decreases by more than 3% for longer than 10 s. This study investigated the association between reduced SpO and parasympathetic nervous system activity (PSNA) during night sleep in young adults (n = 63; aged 20-32 years). Changes in PSNA were measured every minute for 24 h during a free-moving day using an ActiveTracer accelerometer. Pulse oximetry was performed simultaneously during sleep. All participants had significantly lower PSNA when the SpO decreased by 3% or more than when it did not. There were no significant differences in PSNA when an ODI cutoff of 5 events/h was used. However, participants with an ODI >5 events/h had significantly lower PSNA during normal SpO than those with an ODI <5 events/h, suggesting an association between SpO desaturation and PSNA decline during sleep. A high ODI may indicate reduced PSNA levels during sleep, affecting sleep efficiency. Treatment aimed at reducing the ODI may improve sleep quality, even in young adults.
睡眠呼吸暂停综合征（SAS）与心肺和牙科鼻咽疾病有关。脉搏血氧饱和度（SpO）检测是 SAS 的一种诊断筛查方法。SAS 的严重程度通过氧减饱和指数（ODI）来评估，该指数测量 SpO 下降超过 3%且持续时间超过 10 秒的次数。本研究调查了年轻成年人（n=63；年龄 20-32 岁）夜间睡眠中 SpO 降低与副交感神经系统活动（PSNA）之间的关系。使用 ActiveTracer 加速度计在自由移动日的 24 小时内，每 1 分钟测量一次 PSNA 的变化。同时在睡眠期间进行脉搏血氧饱和度检测。当 SpO 降低 3%或更多时，所有参与者的 PSNA 均显著降低。当使用 ODI 截断值为 5 次/h 时，PSNA 没有显著差异。然而，ODI>5 次/h 的参与者在正常 SpO 期间的 PSNA 明显低于 ODI<5 次/h 的参与者，表明睡眠期间 SpO 饱和度降低与 PSNA 下降之间存在关联。高 ODI 可能表明睡眠期间 PSNA 水平降低，影响睡眠效率。旨在降低 ODI 的治疗可能会改善睡眠质量，即使是在年轻成年人中。
