Central Research Laboratory, Hamamatsu Photonics K.K, Shizuoka, Japan.
Division of Neonatology, Saitama Children's Medical Center, Saitama, Japan.
Adv Exp Med Biol. 2024;1463:221-226. doi: 10.1007/978-3-031-67458-7_37.
Recent advances in neonatal intensive care have improved the survival rates of extremely low-birth-weight infants (ELBWIs). However, there has been no obvious improvement in the proportion of survivors without sequelae. Therefore, the development of appropriate management methods for ELBWIs in the neonatal intensive care unit is important to improve outcomes. In this study, we utilised time-domain near-infrared spectroscopy (TD-NIRS) for deep brain monitoring in premature infants in the clinical setting and measured the heads of three ELBWIs once weekly using a TD-NIRS system in transmittance mode. We found that optical signals transmitted through the head were detectable in all ELBWIs. We also confirmed that the total haemoglobin concentration and tissue oxygen saturation decreased in the first month after birth, while the reduced scattering coefficient was not correlated with postmenstrual age. We anticipate that this TD-NIRS technique will be useful for clinical assessment of deep brain tissues for appropriate management of cerebral circulation of ELBWIs in the neonatal intensive care unit.
新生儿重症监护的最新进展提高了极低出生体重儿（ELBWIs）的存活率。然而，没有后遗症的幸存者比例并没有明显改善。因此，开发适合新生儿重症监护病房中 ELBWIs 的管理方法对于改善结局非常重要。在这项研究中，我们在临床环境中使用时域近红外光谱（TD-NIRS）对早产儿进行深部脑监测，并使用透射模式的 TD-NIRS 系统每周对三名 ELBWIs 的头部进行一次测量。我们发现，通过头部传输的光学信号在所有 ELBWIs 中都是可检测的。我们还证实，出生后第一个月总血红蛋白浓度和组织氧饱和度下降，而还原散射系数与胎龄无关。我们预计，这种 TD-NIRS 技术将有助于对深部脑组织进行临床评估，以对新生儿重症监护病房中 ELBWIs 的脑循环进行适当的管理。
