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让我们更好地失败:用哲学工具改进精神病学中的神经科学研究。

Let's fail better: Using philosophical tools to improve neuroscientific research in psychiatry.

机构信息

Department of Experimental Psychology, Complutense University of Madrid, Madrid, Spain.

Department of General Psychology, Faculty of Psychology, University of Padova, Padova, Italy.

出版信息

Eur J Neurosci. 2024 Nov;60(10):6375-6390. doi: 10.1111/ejn.16552. Epub 2024 Oct 14.

Abstract

Despite predictions that neuroscientific discoveries would revolutionize psychiatry, decades of research have not yet led to clinically significant advances in psychiatric care. For this reason, an increasing number of researchers are recognizing the limitations of a purely biomedical approach in psychiatric research. These researchers call for reevaluating the conceptualization of mental disorders and argue for a non-reductionist approach to mental health. The aim of this paper is to discuss philosophical assumptions that underly neuroscientific research in psychiatry and offer practical tools to researchers for overcoming potential conceptual problems that are derived from those assumptions. Specifically, we will discuss: the analogy problem, questioning whether mental health problems are equivalent to brain disorders, the normativity problem, addressing the value-laden nature of psychiatric categories and the priority problem, which describes the level of analysis (e.g., biological, psychological, social, etc.) that should be prioritized when studying psychiatric conditions. In addition, we will explore potential strategies to mitigate practical problems that might arise due to these implicit assumptions. Overall, the aim of this paper is to suggest philosophical tools of practical use for neuroscientists, demonstrating the benefits of a closer collaboration between neuroscience and philosophy.

摘要

尽管有预测称神经科学的发现将彻底改变精神病学,但几十年来的研究并未在精神科护理方面带来显著的临床进展。出于这个原因,越来越多的研究人员开始认识到,纯粹的生物医学方法在精神科研究中存在局限性。这些研究人员呼吁重新评估精神障碍的概念化,并主张采取非还原论的方法来研究心理健康。本文旨在讨论神经科学在精神病学研究中的哲学假设,并为研究人员提供实用工具,以克服这些假设所带来的潜在概念问题。具体来说,我们将讨论:类比问题,质疑心理健康问题是否等同于大脑障碍;规范性问题,解决精神病学分类中具有价值倾向的性质;以及优先性问题,描述在研究精神疾病时应优先考虑的分析水平(例如,生物、心理、社会等)。此外,我们还将探讨可能的策略来减轻由于这些隐含假设而产生的实际问题。总的来说,本文的目的是为神经科学家提供实用的哲学工具,展示神经科学与哲学更紧密合作的益处。

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