Demgne Léannick Wandji, Tsopmene Ulrich Joël, Kianfé Boris Yotta, Dzoyem Jean Paul, Teponno Rémy Bertrand, Barboni Luciano, Tapondjou Léon Azefack, Ponou Beaudelaire Kemvoufo
Research Unit of Environmental and Applied Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
Nat Prod Res. 2024 Oct 14:1-9. doi: 10.1080/14786419.2024.2415429.
A new saponin namely diosgeninoside (25 -spirost-5-en-3--[--glucopyranosyl (1→2) - --glucuronic acid]) and a new fatty acid betacic acid: ()-8(),9(),10(*)-trihydroxy-11-octadecenoic acid together with six known compounds: --coumaroyl tyramine, ergosta-7,22-dien35triol, -sitosterol, and -sitosterol-3----glucopyranoside, -threitol and soya-cerebroside I were isolated from the methanolic extract of . The structures were elucidated by interpretation of their 1D and 2D NMR spectra and spectrometric data. The methanolic extract, the EtOAc and -BuOH fractions, and several isolated compounds were tested for antibacterial activity against four bacteria (; ; ; and ). The methanolic extract and the EtOAc fraction showed moderate activity against and with MIC value of 128 µg/mL. Compound showed moderate activity against with MIC value of 64 µg/mL.
从[植物名称]的甲醇提取物中分离出一种新的皂苷，即薯蓣皂苷元糖苷（25 - 螺甾 - 5 - 烯 - 3 - [ - 吡喃葡萄糖基（1→2） - - 葡萄糖醛酸]）和一种新的脂肪酸β - 酸：（） - 8（），9（），10（*） - 三羟基 - 11 - 十八碳烯酸，以及六种已知化合物： - 香豆酰酪胺、麦角甾 - 7,22 - 二烯 - 3β，5α - 二醇、β - 谷甾醇、β - 谷甾醇 - 3 - O - β - 吡喃葡萄糖苷、 - 苏糖醇和大豆脑苷脂I。通过对其1D和2D NMR光谱以及光谱数据的解释来阐明结构。对甲醇提取物、乙酸乙酯和正丁醇馏分以及几种分离出的化合物进行了针对四种细菌（[细菌名称1]；[细菌名称2]；[细菌名称3]；和[细菌名称4]）的抗菌活性测试。甲醇提取物和乙酸乙酯馏分对[细菌名称1]和[细菌名称2]表现出中等活性，MIC值为128μg/mL。化合物[化合物编号]对[细菌名称3]表现出中等活性，MIC值为64μg/mL。
