Wang Haozhe, Li Dan, Meng Qingyao, Li Xue, Guo Kangle, Zou Zehua, Peng Jinsong, Sun Yuan, Sun Tiedong
College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, 150040, China.
Center of Pharmaceutical Engineering and Technology, Harbin University of Commerce, Harbin, 150076, China.
Macromol Rapid Commun. 2024 Dec;45(23):e2400415. doi: 10.1002/marc.202400415. Epub 2024 Oct 14.
Bacterial infection of wound surfaces has posed a significant threat to human health and represents a formidable challenge in the clinical treatment. In this study, a novel antimicrobial hydrogel utilizing POM is synthesized as the primary component, with gelatin and sodium alginate as the structural framework. The resultant hydrogel demonstrates exceptional mechanical properties and viscoelasticity attributed to the hydrogen-bonded cross-linking between POM and gelatin, as well as the ionic cross-linking between sodium alginate and Ca. In addition, the integration of CuS nanoparticles conferred photothermal properties to the hydrogel system. To address the concerns regarding the potential thermal damage to the surrounding normal cells, this study employs a LT-PTT combined with CDT approach to achieve the enhanced antimicrobial efficacy while minimizing the inadvertent harm to the healthy cells. The findings suggested that POM-based hydrogels, serving as an inorganic-organic hybrid material, will represent a promising antimicrobial solution and offer valuable insights for the development of the non-antibiotic materials.
创面的细菌感染对人类健康构成了重大威胁，是临床治疗中的一项艰巨挑战。在本研究中，一种以聚氧化钼（POM）为主要成分、明胶和海藻酸钠为结构框架合成了一种新型抗菌水凝胶。所得水凝胶表现出优异的机械性能和粘弹性，这归因于POM与明胶之间的氢键交联以及海藻酸钠与钙之间的离子交联。此外，硫化铜纳米颗粒的整合赋予了水凝胶系统光热性能。为了解决对周围正常细胞潜在热损伤的担忧，本研究采用了低强度光热疗法（LT-PTT）与化学动力疗法（CDT）相结合的方法，以在将对健康细胞的意外损害降至最低的同时实现增强的抗菌效果。研究结果表明，基于POM的水凝胶作为一种无机-有机杂化材料，将成为一种有前景的抗菌解决方案，并为非抗生素材料的开发提供有价值的见解。
