Lin Xiaoyang, Liu Huituan, Su Suping, Liu Lu, Tang Yuwen, Chen Zhiwei, Zhang Yuqiong, Liu Zhenhuan
Department of Pediatric Rehabilitation, Affiliated Dongguan Maternal and Child Health Care Hospital, Dongguan 523057, Guangdong Province, China.
Nanhai Women and Children Hospital Affiliated to Guangzhou University of CM; Famous Medical Studio of LIU Zhenhuan.
Zhongguo Zhen Jiu. 2024 Oct 12;44(10):1149-54. doi: 10.13703/j.0255-2930.20231115-0006.
To compare the clinical effect of thumbtack needle at front- points combined with conventional rehabilitation training and simple conventional rehabilitation training in the treatment of autism spectrum disorders (ASD).
A total of 40 children with ASD were randomly divided into a combination group (20 cases, 3 cases dropped out) and a conventional rehabilitation group (20 cases, 3 cases dropped out). Conventional rehabilitation training i.e. language-cognition training and comprehensive education training was adopted in the conventional rehabilitation group, once a day, 5 days a week. On the basis of the treatment in the conventional rehabilitation group, thumbtack needle was applied at Zhongwan (CV 12), bilateral Tianshu (ST 25) and Guanyuan (CV 4) in the combination group, the needles were retained for 3 days each time, 3-day interval was taken between each treatment, for 5 times per month. One-month treatment was as one course and a total of 3 courses were required in both groups, with 10-day break between each course. Before and after treatment, the scores of autism behavior checklist (ABC), childhood autism rating scale (CARS), TCM spleen-stomach symptoms and Achenbach child behavior checklist (CBCL) were observed, and the serum ratio of glutamate and gamma-aminobutyric acid (Glu/GABA) was measured.
After treatment, the scores of ABC, CARS and CBCL were decreased compared with those before treatment (<0.05, <0.01) in both groups, the TCM spleen-stomach symptoms score was decreased compared with that before treatment (<0.05) in the combination group; the changes in the scores of ABC, CARS, TCM spleen-stomach symptoms and CBCL, as well as the serum Glu/GABA in the combination group were lager than those in the conventional rehabilitation group (<0.05, <0.01).
Both thumbtack needle at front- points combined with conventional rehabilitation training and simple conventional rehabilitation training can effectively treat ASD, the combination treatment has superior effect on improving the abnormal behavior, spleen-stomach symptoms and balance of nerve impulse and inhibition.
比较揿针穴位前点结合传统康复训练与单纯传统康复训练治疗孤独症谱系障碍（ASD）的临床疗效。
将40例ASD患儿随机分为联合组（20例，脱落3例）和传统康复组（20例，脱落3例）。传统康复组采用传统康复训练，即语言认知训练和综合教育训练，每日1次，每周5天。联合组在传统康复组治疗的基础上，于中脘（CV 12）、双侧天枢（ST 25）和关元（CV 4）应用揿针，每次留针3天，每次治疗间隔3天，每月5次。以1个月治疗为1个疗程，两组均共需3个疗程，疗程间休息10天。观察治疗前后孤独症行为量表（ABC）评分、儿童孤独症评定量表（CARS）评分、中医脾胃症状评分及艾森克儿童行为量表（CBCL）评分，并检测血清谷氨酸与γ-氨基丁酸比值（Glu/GABA）。
治疗后，两组ABC、CARS及CBCL评分均较治疗前降低（<0.05，<0.01），联合组中医脾胃症状评分较治疗前降低（<0.05）；联合组ABC、CARS、中医脾胃症状及CBCL评分变化及血清Glu/GABA变化幅度均大于传统康复组（<0.05，<0.01）。
揿针穴位前点结合传统康复训练与单纯传统康复训练均能有效治疗ASD，联合治疗在改善异常行为、脾胃症状及神经冲动与抑制平衡方面效果更优。
