衰老和急性损伤中衰老标志物p21v1和p21v2对p53的依赖性

Kar Parmita, Sivasailam Ashok, Lavarti Rupa, Cai Lun, Thangaraju Muthusamy, Nguyen Emma, Mundluru Bhavishya, Raju Raghavan Pillai

Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, USA.

Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, USA.

NPJ Aging. 2024 Oct 14;10(1):45. doi: 10.1038/s41514-024-00175-z.

The senescence phenotype is heterogeneous, as observed by the context-dependent differential expression of senescence markers. Here, we provide evidence to demonstrate an inverse relationship in the expression pattern of the two murine variants of p21 (p21v1, and p21v2) in aging and hemorrhagic shock. While an upregulation of p21v1 was observed following hemorrhagic shock injury, p21v2 was upregulated in the aged mouse. We further show that the p21v1 response is, at least, partially independent of p53.

正如通过衰老标志物的上下文依赖性差异表达所观察到的那样，衰老表型是异质性的。在这里，我们提供证据证明在衰老和失血性休克中，p21的两种小鼠变体（p21v1和p21v2）的表达模式呈负相关。虽然在失血性休克损伤后观察到p21v1上调，但p21v2在老年小鼠中上调。我们进一步表明，p21v1的反应至少部分独立于p53。