多基因评分方法之间胚胎选择不一致。 - Suppr

Inconsistent embryo selection across polygenic score methods.

作者信息

Namba Shinichi, Akiyama Masato, Hamanoue Haruka, Kato Kazuto, Kawashima Minae, Kushima Itaru, Matsuda Koichi, Nakatochi Masahiro, Ogishima Soichi, Sonehara Kyuto, Suzuki Ken, Takata Atsushi, Tamiya Gen, Tanikawa Chizu, Yamamoto Kenichi, Yamamoto Natsuko, Ozaki Norio, Okada Yukinori

机构信息

Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Department of Statistical Genetics, Graduate School of Medicine, Osaka University, Suita, Japan.

出版信息

Nat Hum Behav. 2024 Dec;8(12):2264-2267. doi: 10.1038/s41562-024-02019-y.

DOI:10.1038/s41562-024-02019-y

PMID:39402258

Abstract

摘要

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本文引用的文献

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Public views on polygenic screening of embryos.

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Problems with Using Polygenic Scores to Select Embryos.

N Engl J Med. 2021 Jul 1;385(1):78-86. doi: 10.1056/NEJMsr2105065.

Polygenic risk scores: from research tools to clinical instruments.

Genome Med. 2020 May 18;12(1):44. doi: 10.1186/s13073-020-00742-5.

The pros and cons of preimplantation genetic testing for aneuploidy: clinical and laboratory perspectives.

Fertil Steril. 2018 Aug;110(3):353-361. doi: 10.1016/j.fertnstert.2018.06.002.

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相似文献

Inconsistent embryo selection across polygenic score methods.

Nat Hum Behav. 2024 Dec;8(12):2264-2267. doi: 10.1038/s41562-024-02019-y.

Three models for the regulation of polygenic scores in reproduction.

J Med Ethics. 2021 Jan 18;47(12):e91. doi: 10.1136/medethics-2020-106588.

Divergence Between Clinician and Patient Perspectives on Polygenic Embryo Screening: A Qualitative Study.

medRxiv. 2023 Oct 13:2023.10.12.23296961. doi: 10.1101/2023.10.12.23296961.

Polygenic risk score for embryo selection-not ready for prime time.

Hum Reprod. 2022 Sep 30;37(10):2229-2236. doi: 10.1093/humrep/deac159.

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Philos Trans R Soc Lond B Biol Sci. 2022 Jun 6;377(1852):20200416. doi: 10.1098/rstb.2020.0416. Epub 2022 Apr 18.

Clinical utility of polygenic risk scores for embryo selection: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG).

Genet Med. 2024 Apr;26(4):101052. doi: 10.1016/j.gim.2023.101052. Epub 2024 Feb 23.

Concerns about the use of polygenic embryo screening for psychiatric and cognitive traits.

Lancet Psychiatry. 2022 Oct;9(10):838-844. doi: 10.1016/S2215-0366(22)00157-2. Epub 2022 Aug 2.

Polygenic risk scoring of human embryos: a qualitative study of media coverage.

BMC Med Ethics. 2021 Sep 18;22(1):125. doi: 10.1186/s12910-021-00694-4.

Utility and First Clinical Application of Screening Embryos for Polygenic Disease Risk Reduction.

Front Endocrinol (Lausanne). 2019 Dec 4;10:845. doi: 10.3389/fendo.2019.00845. eCollection 2019.

Screening Human Embryos for Polygenic Traits Has Limited Utility.

Cell. 2019 Nov 27;179(6):1424-1435.e8. doi: 10.1016/j.cell.2019.10.033. Epub 2019 Nov 21.

引用本文的文献

The Role of Polygenic Risk Score in the General Population: Current Status and Future Prospects.

J Atheroscler Thromb. 2025 Sep 1;32(9):1079-1097. doi: 10.5551/jat.RV22039. Epub 2025 Jul 4.

Evaluating Performance and Agreement of Coronary Heart Disease Polygenic Risk Scores.

JAMA. 2025 Jan 7;333(1):60-70. doi: 10.1001/jama.2024.23784.

本文引用的文献

Rank concordance of polygenic indices.

Nat Hum Behav. 2023 May;7(5):802-811. doi: 10.1038/s41562-023-01544-6. Epub 2023 Mar 13.

Public views on polygenic screening of embryos.

Science. 2023 Feb 10;379(6632):541-543. doi: 10.1126/science.ade1083. Epub 2023 Feb 9.

Evaluating standards for 'serious' disease for preimplantation genetic testing: a multi-case study on regulatory frameworks in Japan, the UK, and Western Australia.

Hum Genomics. 2022 May 18;16(1):16. doi: 10.1186/s40246-022-00390-3.

Whole-genome risk prediction of common diseases in human preimplantation embryos.

Nat Med. 2022 Mar;28(3):513-516. doi: 10.1038/s41591-022-01735-0. Epub 2022 Mar 21.

Embryo Screening for Polygenic Disease Risk: Recent Advances and Ethical Considerations.

Genes (Basel). 2021 Jul 21;12(8):1105. doi: 10.3390/genes12081105.

Problems with Using Polygenic Scores to Select Embryos.

N Engl J Med. 2021 Jul 1;385(1):78-86. doi: 10.1056/NEJMsr2105065.

Polygenic risk scores: from research tools to clinical instruments.

Genome Med. 2020 May 18;12(1):44. doi: 10.1186/s13073-020-00742-5.

The pros and cons of preimplantation genetic testing for aneuploidy: clinical and laboratory perspectives.

Fertil Steril. 2018 Aug;110(3):353-361. doi: 10.1016/j.fertnstert.2018.06.002.

Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations.

Am J Hum Genet. 2017 Apr 6;100(4):635-649. doi: 10.1016/j.ajhg.2017.03.004. Epub 2017 Mar 30.

Inconsistent embryo selection across polygenic score methods.

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Inconsistent embryo selection across polygenic score methods.

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