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Inconsistent embryo selection across polygenic score methods.

作者信息

Namba Shinichi, Akiyama Masato, Hamanoue Haruka, Kato Kazuto, Kawashima Minae, Kushima Itaru, Matsuda Koichi, Nakatochi Masahiro, Ogishima Soichi, Sonehara Kyuto, Suzuki Ken, Takata Atsushi, Tamiya Gen, Tanikawa Chizu, Yamamoto Kenichi, Yamamoto Natsuko, Ozaki Norio, Okada Yukinori

机构信息

Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Department of Statistical Genetics, Graduate School of Medicine, Osaka University, Suita, Japan.

出版信息

Nat Hum Behav. 2024 Dec;8(12):2264-2267. doi: 10.1038/s41562-024-02019-y.

DOI:10.1038/s41562-024-02019-y
PMID:39402258
Abstract
摘要

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本文引用的文献

1
Rank concordance of polygenic indices.多基因指数的等级一致性。
Nat Hum Behav. 2023 May;7(5):802-811. doi: 10.1038/s41562-023-01544-6. Epub 2023 Mar 13.
2
Public views on polygenic screening of embryos.公众对胚胎多基因筛查的看法。
Science. 2023 Feb 10;379(6632):541-543. doi: 10.1126/science.ade1083. Epub 2023 Feb 9.
3
Evaluating standards for 'serious' disease for preimplantation genetic testing: a multi-case study on regulatory frameworks in Japan, the UK, and Western Australia.评估着床前基因检测“严重”疾病的标准:日本、英国和西澳大利亚监管框架的多案例研究。
Hum Genomics. 2022 May 18;16(1):16. doi: 10.1186/s40246-022-00390-3.
4
Whole-genome risk prediction of common diseases in human preimplantation embryos.人类胚胎着床前全基因组常见疾病风险预测。
Nat Med. 2022 Mar;28(3):513-516. doi: 10.1038/s41591-022-01735-0. Epub 2022 Mar 21.
5
Embryo Screening for Polygenic Disease Risk: Recent Advances and Ethical Considerations.胚胎多基因疾病风险筛查:最新进展与伦理考量。
Genes (Basel). 2021 Jul 21;12(8):1105. doi: 10.3390/genes12081105.
6
Problems with Using Polygenic Scores to Select Embryos.使用多基因评分选择胚胎存在的问题。
N Engl J Med. 2021 Jul 1;385(1):78-86. doi: 10.1056/NEJMsr2105065.
7
Polygenic risk scores: from research tools to clinical instruments.多基因风险评分:从研究工具到临床工具。
Genome Med. 2020 May 18;12(1):44. doi: 10.1186/s13073-020-00742-5.
8
The pros and cons of preimplantation genetic testing for aneuploidy: clinical and laboratory perspectives.胚胎植入前非整倍体基因检测的利弊:临床与实验室视角
Fertil Steril. 2018 Aug;110(3):353-361. doi: 10.1016/j.fertnstert.2018.06.002.
9
Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations.人类人口统计学历史影响不同人群的遗传风险预测。
Am J Hum Genet. 2017 Apr 6;100(4):635-649. doi: 10.1016/j.ajhg.2017.03.004. Epub 2017 Mar 30.