Department of Nursing, College of Health Science, Woldia University, Woldia, Ethiopia.
School of Medicine, College of Health Science, Woldia University, Woldia, Ethiopia.
BMC Public Health. 2024 Oct 14;24(1):2816. doi: 10.1186/s12889-024-20300-7.
Erectile dysfunction is no longer a whisper in the shadows; it's a rising tide threatening the sexual health of millions of men in different regions. In the cases of diabetes, the condition worsens and has a potent cocktail of physical and psychological distress, chipping away at men's confidence, self-esteem, and mental health. This worrying trend shows no signs of slowing down, with projections claiming a staggering 322 million men globally could be affected in the near future. This urgent issue demands immediate attention and action. Thus, this umbrella review intended to estimate the current burden of erectile dysfunction and associated risk factors among diabetic patients in the global context.
Following PRISMA guidelines, we searched for relevant studies in PubMed, Embase, Scopus, Web of Science, Cochrane Database of Systematic Reviews, and Google Scholar. These studies reported the prevalence of erectile dysfunction and associated risk factors in diabetic patients. The quality of the included studies was assessed using the Assessment of Multiple Systematic Reviews 2 tool. To estimate the pooled prevalence of erectile dysfunction, we employed a weighted inverse variance random-effects model. We further conducted subgroup analyses, assessed heterogeneity and publication bias, and performed sensitivity analyses to strengthen the robustness of our findings. Prediction intervals were also calculated to estimate the range within which future observations will likely fall. In all statistical analyses, the statistical significance was declared at P- value < 0.05.
In this umbrella review, a total of 108 030 male diabetic patients were included to estimate the global prevalence of erectile dysfunction. The pooled global prevalence of erectile dysfunction in diabetic patients was 65.8% (95CI: 58.3 - 73.3%), while In Africa it was 62.9% (95CI: 46.1-79.7). Age (> 40 years) (AOR = 1.95, 95CI: 1.03-3.24), DM duration (> 10years) (AOR = 1.90,95CI: 1.16-2.65), peripheral vascular disease (AOR = 2.74, 95CI: 1.42-4.06) and BMI (> 30 kg/m2) (AOR = 1.07,95CI: 1.01-1.20) were identified as associated risk factors of erectile dysfunction in diabetic patient.
The high global prevalence of erectile dysfunction (ED) in diabetic patients is alarming, with an estimated two-thirds experiencing the condition. These findings underscore the significant burden of ED faced by diabetic men and emphasize the urgent need for global attention to the issue. This includes promoting early screening for erectile dysfunction in this population and ensuring access to appropriate treatment and support.
勃起功能障碍不再是暗处的低语，而是威胁着全球数以百万计男性性健康的汹涌浪潮。在糖尿病的情况下，这种情况会恶化，并伴随着身体和心理上的困扰，削弱男性的信心、自尊心和心理健康。这种令人担忧的趋势没有放缓的迹象，预测在不久的将来，全球可能会有 3.22 亿男性受到影响。这个紧迫的问题需要立即关注和采取行动。因此，这项伞式综述旨在估计全球范围内糖尿病患者勃起功能障碍的当前负担和相关危险因素。
根据 PRISMA 指南，我们在 PubMed、Embase、Scopus、Web of Science、Cochrane 系统评价数据库和 Google Scholar 中搜索了相关研究。这些研究报告了糖尿病患者勃起功能障碍的流行率和相关危险因素。使用评估多个系统评价 2 工具评估纳入研究的质量。为了估计勃起功能障碍的总流行率，我们采用了加权逆方差随机效应模型。我们还进行了亚组分析、评估异质性和发表偏倚，并进行敏感性分析，以增强我们发现的稳健性。还计算了预测区间，以估计未来观察结果可能落入的范围。在所有统计分析中，均以 P 值<0.05 表示统计显著性。
在这项伞式综述中，共纳入了 108030 名男性糖尿病患者，以估计全球勃起功能障碍的流行率。糖尿病患者勃起功能障碍的全球总流行率为 65.8%（95%置信区间：58.3-73.3%），而在非洲为 62.9%（95%置信区间：46.1-79.7%）。年龄（>40 岁）（OR=1.95，95%置信区间：1.03-3.24）、DM 持续时间（>10 年）（OR=1.90，95%置信区间：1.16-2.65）、外周血管疾病（OR=2.74，95%置信区间：1.42-4.06）和 BMI（>30kg/m2）（OR=1.07，95%置信区间：1.01-1.20）被确定为糖尿病患者勃起功能障碍的相关危险因素。
糖尿病患者勃起功能障碍（ED）的全球高患病率令人震惊，估计有三分之二的患者患有这种疾病。这些发现突显出糖尿病男性面临的 ED 负担的重大性，并强调了全球对这一问题的迫切关注。这包括在该人群中促进早期筛查勃起功能障碍，并确保获得适当的治疗和支持。
