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本文引用的文献

1
Evaluating fentanyl test strips as a harm reduction strategy in rural and urban counties: study protocol for a randomized controlled trial.评估芬太尼检测条作为农村和城市县减少伤害的策略:一项随机对照试验的研究方案。
Trials. 2024 Sep 4;25(1):587. doi: 10.1186/s13063-024-08440-y.
2
Evaluation of the relationship of xylazine and fentanyl blood concentrations among fentanyl-associated fatalities.芬太尼相关死亡案例中甲苯噻嗪与芬太尼血药浓度关系的评估。
Clin Toxicol (Phila). 2024 Jan;62(1):26-31. doi: 10.1080/15563650.2024.2309326. Epub 2024 Feb 14.
3
Xylazine Use Among People Who Inject Drugs, Philadelphia 2022.2022 年费城注射吸毒者中使用苯环己哌啶的情况。
J Addict Med. 2024;18(2):194-200. doi: 10.1097/ADM.0000000000001264. Epub 2024 Jan 30.
4
Xylazine in Overdose Deaths and Forensic Drug Reports in US States, 2019-2022.2019-2022 年美国各州过量死亡和法医毒品报告中的苯环己哌啶
JAMA Netw Open. 2024 Jan 2;7(1):e2350630. doi: 10.1001/jamanetworkopen.2023.50630.
5
"Tranq-dope" overdose and mortality: lethality induced by fentanyl and xylazine.“镇静-麻醉药”过量与死亡率:芬太尼和赛拉嗪所致的致死性
Front Pharmacol. 2023 Oct 26;14:1280289. doi: 10.3389/fphar.2023.1280289. eCollection 2023.
6
Self-reported Xylazine Experiences: A Mixed-methods Study of Reddit Subscribers.自我报告的苯佐卡因使用体验:对 Reddit 订阅者的混合方法研究。
J Addict Med. 2023;17(6):691-694. doi: 10.1097/ADM.0000000000001216. Epub 2023 Aug 10.
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Reducing the harms of xylazine: clinical approaches, research deficits, and public health context.减少苯环己哌啶(Xylazine)的危害:临床方法、研究不足和公共卫生背景。
Harm Reduct J. 2023 Sep 30;20(1):141. doi: 10.1186/s12954-023-00879-7.
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Xylazine in the drug supply: Emerging threats and lessons learned in areas with high levels of adulteration.药品供应中的赛拉嗪:掺假率高的地区出现的新威胁及经验教训
Int J Drug Policy. 2023 Oct;120:104154. doi: 10.1016/j.drugpo.2023.104154. Epub 2023 Aug 11.
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Illicitly Manufactured Fentanyl-Involved Overdose Deaths with Detected Xylazine - United States, January 2019-June 2022.非法制造的芬太尼涉及到的过量死亡与检出的苯环己哌啶有关-美国,2019 年 1 月至 2022 年 6 月。
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Xylazine effects on opioid-induced brain hypoxia.盐酸二甲啡烷对阿片类药物引起的脑缺氧的影响。
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俄亥俄州吸毒者对苯环己哌啶(苯环己哌啶,俗称“听话水”)的认知和态度,2023-2024 年。

Xylazine awareness and attitudes among people who use drugs in Ohio, 2023-2024.

机构信息

Center for Injury Research and Policy, Abigail Wexner Research Institute at Nationwide Children's Hospital, 575 Children's Crossroad, Columbus, OH, 43215, USA.

Department of Pediatrics, College of Medicine, The Ohio State University, 370 W. 9th Avenue, Columbus, OH, 43210, USA.

出版信息

Harm Reduct J. 2024 Oct 14;21(1):182. doi: 10.1186/s12954-024-01097-5.

DOI:10.1186/s12954-024-01097-5
PMID:39402530
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11479538/
Abstract

BACKGROUND

The prevalence of xylazine, a non-opioid tranquilizer not for human consumption, in illicitly manufactured fentanyl is increasing in the United States. However, little is known about xylazine awareness and attitudes among people who use drugs.

METHODS

A cross-sectional survey of people who use drugs in Ohio was conducted from November 2023 - May 2024 to identify xylazine awareness and attitudes in rural and urban counties across the state. Study participants were recruited from naloxone distribution sites, including health departments, syringe service programs, and community-based organizations.

RESULTS

Among 630 people who use drugs in Ohio, more than one-half (53.5%) were unaware of xylazine being in "street drugs," regardless of urbanicity. Among individuals who were aware of xylazine, most (73.0%) indicated they did not want to use the drug and try to avoid it. In addition, 75.8% of this group felt it was "very" or "extremely" important to know if xylazine was in their drugs.

DISCUSSION

This research found that many people who use drugs in Ohio are unaware of xylazine and its risks. An important finding of this study is that most individuals who had heard of xylazine did not want to use it and were concerned about knowing whether xylazine was in their drugs.

摘要

背景

在美国,非阿片类镇静剂苯环己哌啶(xylazine)在非法制造的芬太尼中的流行率正在上升。然而,人们对吸毒者中苯环己哌啶的认识和态度知之甚少。

方法

2023 年 11 月至 2024 年 5 月,在俄亥俄州进行了一项横断面调查,以确定该州农村和城市县中吸毒者对苯环己哌啶的认识和态度。研究参与者是从纳洛酮分发点招募的,包括卫生部门、注射器服务项目和社区组织。

结果

在俄亥俄州的 630 名吸毒者中,超过一半(53.5%)的人不知道苯环己哌啶存在于“街头毒品”中,无论城市状况如何。在意识到苯环己哌啶存在的人中,大多数(73.0%)表示他们不想使用该药物并试图避免使用。此外,该组中有 75.8%的人认为知道他们的药物中是否含有苯环己哌啶“非常”或“极其”重要。

讨论

这项研究发现,俄亥俄州的许多吸毒者不知道苯环己哌啶及其风险。这项研究的一个重要发现是,大多数听说过苯环己哌啶的人都不想使用它,并担心知道他们的药物中是否含有苯环己哌啶。