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青少年芬太尼使用:毒理学风险、流行病学趋势及公共卫生策略

Adolescent Fentanyl Use: Toxicological Risks, Epidemiological Trends, and Public Health Strategies.

作者信息

Sacco Matteo Antonio, Gualtieri Saverio, Santos Agostinho, Mendes Bárbara, Aquila Isabella

机构信息

Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, ITA.

Department of Legal Medicine and Forensic Sciences, Faculty of Medicine, University of Porto, Porto, PRT.

出版信息

Cureus. 2025 Feb 24;17(2):e79558. doi: 10.7759/cureus.79558. eCollection 2025 Feb.

Abstract

Fentanyl has become a critical public health concern due to its increasing presence in illicit drug markets and its role in the rising number of opioid-related fatalities, particularly among adolescents. This study examines the toxicological properties of fentanyl, its accessibility through online platforms, and the behavioral factors contributing to its misuse in adolescent populations. Key findings highlight the high risk of overdose due to fentanyl's potency, especially when combined with substances such as alcohol and benzodiazepines. Epidemiological data reveal a dramatic surge in adolescent fentanyl-related deaths, exacerbated by counterfeit prescription drugs and a lack of awareness regarding its extreme potency. The study also explores prevention and intervention strategies, including public health education, harm reduction approaches, and policy recommendations aimed at mitigating the growing crisis. Addressing this issue requires a multifaceted approach, integrating medical, social, and legislative efforts to protect vulnerable adolescent populations.

摘要

由于芬太尼在非法毒品市场中越来越常见,且在与阿片类药物相关的死亡人数上升中扮演重要角色,尤其是在青少年群体中,它已成为一个关键的公共卫生问题。本研究考察了芬太尼的毒理学特性、通过在线平台获取芬太尼的情况,以及导致其在青少年人群中滥用的行为因素。主要研究结果凸显了由于芬太尼效力强大而导致过量用药的高风险,尤其是当它与酒精和苯二氮䓬类等物质合用时。流行病学数据显示,青少年芬太尼相关死亡人数急剧飙升,假冒处方药以及对其极端效力缺乏认识使情况更加恶化。该研究还探讨了预防和干预策略,包括公共卫生教育、减少伤害的方法,以及旨在缓解这一日益严重危机的政策建议。解决这一问题需要采取多方面的方法,整合医疗、社会和立法方面的努力,以保护易受伤害的青少年群体。

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