Li Juan, Zhang Qiang, Wang Juan, Xiong Ying, Zhu Wenzhen
Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Diabetol Metab Syndr. 2024 Oct 15;16(1):247. doi: 10.1186/s13098-024-01484-9.
To explore the topological organization alterations of functional connectomes in type 2 diabetes (T2DM) patients with and without mild cognitive impairment (MCI), and compare these with structural connectomes changes.
Twenty-six T2DM patients with MCI (DM-MCI), 26 without cognitive impairment (DM-NC), and 28 healthy controls were included. Diffusion tensor imaging (DTI) and resting-state functional MRI images were acquired. Networks were constructed and graph-theory based network measurements were calculated. The global network parameters and nodal efficiencies were compared across the three groups using one-way ANOVA and a false-discovery rate correction was applied for multiple comparisons. Partial correlation analyses were performed to investigate relationships between network parameters, cognitive performance and clinical variables.
In the structural connectome, the DM-MCI group exhibited significantly decreased global efficiency (E) and local efficiency (E) compared to the DM-NC and control groups. In the functional connectome, the DM-MCI group exhibited increased E and clustering coefficient (Cp) compared to the controls. No significant differences were found in E, E, or Cp between the DM-NC and the control group, both in structural and functional connectomes. Nodal efficiencies decreased in some brain regions of structural and functional networks in the DM-MCI and DM-NC groups, but increased in five regions in functional network, some of which were involved in the default-mode network.
Unlike the consistently decreased global properties and nodal efficiencies in the structural connectome of T2DM patients, increases in E, Cp, and nodal efficiencies in the functional connectome may be viewed as a compensatory mechanism due to functional plasticity and reorganization. Altered nodal efficiency can hint at cognitive decrements at an early stage in T2DM patients.
探讨伴有和不伴有轻度认知障碍（MCI）的2型糖尿病（T2DM）患者功能连接组的拓扑组织改变，并将其与结构连接组的变化进行比较。
纳入26例伴有MCI的T2DM患者（DM-MCI组）、26例无认知障碍的T2DM患者（DM-NC组）和28名健康对照者。采集弥散张量成像（DTI）和静息态功能磁共振成像（MRI）图像。构建网络并计算基于图论的网络测量值。使用单因素方差分析比较三组的全局网络参数和节点效率，并应用错误发现率校正进行多重比较。进行偏相关分析以研究网络参数、认知表现和临床变量之间的关系。
在结构连接组中，与DM-NC组和对照组相比，DM-MCI组的全局效率（E）和局部效率（E）显著降低。在功能连接组中，与对照组相比，DM-MCI组的E和聚类系数（Cp）增加。在结构和功能连接组中，DM-NC组和对照组之间的E、E或Cp均无显著差异。DM-MCI组和DM-NC组的结构和功能网络的某些脑区节点效率降低，但功能网络中有五个区域的节点效率增加，其中一些区域参与默认模式网络。
与T2DM患者结构连接组中全局属性和节点效率持续降低不同，功能连接组中E、Cp和节点效率的增加可能被视为由于功能可塑性和重组而产生的一种代偿机制。节点效率的改变可能暗示T2DM患者早期的认知减退。
