Grome J J, Harper A M
J Neurochem. 1986 Jan;46(1):117-24. doi: 10.1111/j.1471-4159.1986.tb12933.x.
Substances with varying structural components have been shown to have 5-hydroxytryptamine (5-HT)-like properties in the CNS. In this study, putative 5-HT agonists with indoleamine moeities--lysergic acid diethylamide (LSD) and 5-methoxy-N,N-dimethyltryptamine (5-MeODMT)--and with piperazine moieties--quipazine (Quip) and 6-chloro-2-(1-piperazinyl)pyrazine (6-CPP) were administered to rats. Local cerebral glucose utilisation was measured using the [14C]2-deoxyglucose autoradiographic technique. It was found that in most cerebral structures, these substances produced dose-dependent reductions in glucose utilisation. However, Quip and 6-CPP increased glucose utilisation in specific areas of the diencephalon (e.g., nucleus reuniens) and produced a biphasic effect in some but not all extrapyramidal structures (e.g., ventromedial caudate nucleus). No such increases in local cerebral glucose utilisation were measured following LSD or 5-MeODMT administration. These results indicate that although similarities exist between the effects of indoleamine- and piperazine-containing 5-HT agonists on local cerebral glucose utilisation there are also significant differences in the overall patterns of response produced.
结构成分各异的物质已被证明在中枢神经系统中具有5-羟色胺（5-HT）样特性。在本研究中，将含有吲哚胺基团的假定5-HT激动剂——麦角酸二乙酰胺（LSD）和5-甲氧基-N,N-二甲基色胺（5-MeODMT），以及含有哌嗪基团的——喹哌嗪（Quip）和6-氯-2-(1-哌嗪基)吡嗪（6-CPP）给予大鼠。使用[14C]2-脱氧葡萄糖放射自显影技术测量局部脑葡萄糖利用情况。结果发现，在大多数脑结构中，这些物质会使葡萄糖利用呈剂量依赖性降低。然而，喹哌嗪和6-CPP会增加间脑特定区域（如 reuniens核）的葡萄糖利用，并在一些但并非所有锥体外系结构（如腹内侧尾状核）中产生双相效应。给予LSD或5-MeODMT后未测得局部脑葡萄糖利用的此类增加。这些结果表明，尽管含吲哚胺和哌嗪的5-HT激动剂对局部脑葡萄糖利用的影响存在相似之处，但所产生的总体反应模式也存在显著差异。
