Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610032, China; Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China; TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610032, China.
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610032, China; Jiangsu Province Hospital of Chinese Medicine, Nanjing 210004, China.
Phytomedicine. 2024 Jul;129:155663. doi: 10.1016/j.phymed.2024.155663. Epub 2024 Apr 21.
Allergic rhinitis (AR) is a non-infectious chronic inflammation of the nasal mucosa mainly mediated by immunoglobulin E (IgE) in atopic individuals after exposure to allergens. The application of AR guideline-recommended pharmacotherapies can rapidly relieve symptoms of AR but with poor long-term efficacy, and many of these therapies have side effects. Many natural products and their derivatives have shown potential therapeutic effects on AR with fewer side effects.
This review aims to expand understanding of the roles and mechanisms of natural compounds in the treatment of AR and to highlight the importance of utilizing natural products in the treatment of AR.
We conducted a systematic literature search using PubMed, Web of Science, Google Scholar, and Clinical Trials. The search was performed using keywords including natural products, natural compounds, bioproducts, plant extracts, naturally derived products, natural resources, allergic rhinitis, hay fever, pollinosis, nasal allergy. Comprehensive research and compilation of existing literature were conducted.
This article provided a comprehensive review of the potential therapeutic effects and mechanisms of natural compounds in the treatment of AR. We emphasized that natural products primarily exert their effects by modulating signalling pathways such as NF-κB, MAPKs, STAT3/ROR-γt/Foxp3, and GATA3/T-bet, thereby inhibiting the activation and expansion of allergic inflammation. We also discussed their toxicity and clinical applications in AR therapy.
Taken together, natural products exhibit great potential in the treatment of AR. This review is also expected to facilitate the application of natural products as candidates for treating AR. Furthermore, drug discovery based on natural products has a promising prospect in AR treatment.
变应性鼻炎（AR）是一种非传染性的慢性鼻黏膜炎症，主要由特应性个体暴露于过敏原后免疫球蛋白 E（IgE）介导。AR 指南推荐的药物治疗可以迅速缓解 AR 的症状，但长期疗效不佳，且许多治疗方法都有副作用。许多天然产物及其衍生物对 AR 具有潜在的治疗作用，副作用较少。
本综述旨在扩大对天然化合物治疗 AR 作用和机制的认识，并强调利用天然产物治疗 AR 的重要性。
我们使用 PubMed、Web of Science、Google Scholar 和 ClinicalTrials 进行了系统的文献检索。检索使用的关键词包括天然产物、天然化合物、生物制品、植物提取物、天然衍生产品、天然资源、变应性鼻炎、花粉症、过敏性鼻炎、鼻过敏。对现有文献进行了综合研究和汇编。
本文全面综述了天然化合物治疗 AR 的潜在治疗效果和作用机制。我们强调，天然产物主要通过调节 NF-κB、MAPKs、STAT3/ROR-γt/Foxp3 和 GATA3/T-bet 等信号通路发挥作用，从而抑制过敏炎症的激活和扩张。我们还讨论了它们的毒性和在 AR 治疗中的临床应用。
综上所述，天然产物在治疗 AR 方面具有巨大的潜力。本综述也有望促进将天然产物作为治疗 AR 的候选药物的应用。此外，基于天然产物的药物发现在 AR 治疗中具有广阔的前景。
