Zaman Saif, Gorelick Fred
Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06511.
Veteran's Administration Healthcare System, West Haven, CT 06516.
J Pancreatol. 2024 Mar;7(1):10-20. doi: 10.1097/JP9.0000000000000168. Epub 2024 Jan 2.
Acute pancreatitis is a severe inflammatory disorder with limited treatment options. Improved understanding of disease mechanisms has led to new and potential therapies. Here we summarize what we view as some of the most promising new therapies for treating acute pancreatitis, emphasizing the rationale of specific treatments based on disease mechanisms. Targeted pharmacologic interventions are highlighted. We explore potential treatment benefits and risks concerning reducing acute injury, minimizing complications, and improving long-term outcomes. Mechanisms associated with acute pancreatitis initiation, perpetuation, and reconstitution are highlighted, along with potential therapeutic targets and how these relate to new treatments.
急性胰腺炎是一种严重的炎症性疾病，治疗选择有限。对疾病机制的深入了解带来了新的潜在疗法。在此，我们总结了我们认为治疗急性胰腺炎最有前景的一些新疗法，强调基于疾病机制的特定治疗原理。重点介绍了靶向药物干预。我们探讨了在减少急性损伤、将并发症降至最低以及改善长期预后方面潜在的治疗益处和风险。突出了与急性胰腺炎的起始、持续和恢复相关的机制，以及潜在的治疗靶点及其与新疗法的关系。
