Histocompatibility and Immunogenetics Laboratory, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.
Oncology Department, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.
Transfusion. 2021 Jun;61(6):1700-1704. doi: 10.1111/trf.16358. Epub 2021 Mar 11.
Platelet transfusion refractoriness (PTR), defined as an unsatisfactory post-transfusion platelet count increment, is a common complication of patients receiving multiple transfusions. Different strategies are described in the management of PTR. In this work, we demonstrate the efficacy of the detection and identification of anti-HLA antibodies in the recipient using a threshold of 3000 mean fluorescence intensity (MFI), and the seek of donors not expressing HLA antigens against which the patient is immunized.
血小板输注无效（PTR）定义为多次输注患者输血后血小板计数增加不理想，是一种常见并发症。在 PTR 的管理中描述了不同的策略。在这项工作中，我们证明了使用 3000 平均荧光强度（MFI）的阈值来检测和识别受者中的抗 HLA 抗体，并寻找不表达针对患者免疫的 HLA 抗原的供体的有效性。
