Johal Karen, Jones Dan J W, Bell Lynne, Lovegrove Julie A, Lamport Daniel Joseph
School of Psychology and Clinical Language Sciences, University of Reading, Reading RG6 6DZ, UK.
Human Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6DZ, UK.
Nutr Res Rev. 2025 Jun;38(1):393-406. doi: 10.1017/S0954422424000209. Epub 2024 Oct 15.
Coffee drinking has been associated with benefits for various health outcomes, with many attributed to the most prevalent family of polyphenols within coffee, chlorogenic acids (CGA). Whilst reviews of the association between coffee and cognition exist, evidence exploring effects of coffee-specific CGA on cognition has yet to be systematically synthesised. The purpose was to systematically review the current literature investigating the relationship between CGA from coffee and cognitive performance. A further objective was to undertake a meta-analysis of relevant randomised controlled trials (RCT). Observational and intervention studies were included if they considered coffee-based CGA consumption in human participants and applied a standardised measure of cognition. Furthermore, intervention studies were required to define the CGA content and include a control group/placebo. Studies were excluded if they examined CGA alone as an extract or supplement. A search of Scopus, PubMed, Web of Science, ScienceDirect and PsycINFO resulted in including twenty-three papers, six of which were interventions. The evidence from the broader systematic review suggests that CGA from coffee may need to be consumed chronically over a sustained period to produce cognitive benefits. However, the meta-analysis of RCT showed no benefits of coffee CGA intake on cognitive function ( = 0.00, 95% CI -0.05, 0.05). Overall, this review included a limited number of studies, the sample sizes were small, and a wide range of cognitive measures have been utilised. This indicates that further, good-quality interventions and RCT are required to systematically explore the conditions under which coffee CGA may provide benefits for cognitive outcomes.
喝咖啡已被认为对多种健康结果有益，其中许多益处归因于咖啡中最常见的多酚家族——绿原酸（CGA）。虽然已有关于咖啡与认知之间关联的综述，但探索咖啡中特定CGA对认知影响的证据尚未得到系统的综合。目的是系统回顾当前研究咖啡中CGA与认知表现之间关系的文献。另一个目标是对相关随机对照试验（RCT）进行荟萃分析。如果观察性和干预性研究考虑了人类参与者基于咖啡的CGA摄入量并应用了标准化的认知测量方法，则将其纳入。此外，干预性研究需要定义CGA含量并包括对照组/安慰剂。如果研究仅将CGA作为提取物或补充剂进行研究，则将其排除。对Scopus、PubMed、Web of Science、ScienceDirect和PsycINFO的检索结果纳入了23篇论文，其中6篇是干预性研究。更广泛的系统综述证据表明，可能需要长期持续摄入咖啡中的CGA才能产生认知益处。然而，RCT的荟萃分析显示，摄入咖啡CGA对认知功能没有益处（ = 0.00，95% CI -0.05，0.05）。总体而言，本综述纳入的研究数量有限，样本量较小，且使用了广泛的认知测量方法。这表明需要进一步开展高质量的干预措施和RCT，以系统地探索咖啡CGA可能为认知结果带来益处的条件。
