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用于磁共振引导心血管介入的热拉伸聚合物导管

Thermally Drawn Polymeric Catheters for MR-Guided Cardiovascular Intervention.

作者信息

Abdelaziz Mohamed E M K, Tian Libaihe, Lottner Thomas, Reiss Simon, Heidt Timo, Maier Alexander, Düring Klaus, Mühlen Constantin von Zur, Bock Michael, Yeatman Eric, Yang Guang-Zhong, Temelkuran Burak

机构信息

The Hamlyn Centre for Robotic Surgery, Imperial College London, London, SW7 2AZ, UK.

Department of Electrical and Electronic Engineering, Faculty of Engineering, Imperial College London, London, SW7 2AZ, UK.

出版信息

Adv Sci (Weinh). 2024 Dec;11(45):e2407704. doi: 10.1002/advs.202407704. Epub 2024 Oct 15.

Abstract

Cardiovascular diseases (CVDs), including congenital heart diseases (CHD), present significant global health challenges, emphasizing the need for safe and effective treatment modalities. Fluoroscopy-guided endovascular interventions are widely utilized but raise concerns about ionizing radiation, especially in pediatric cases. Magnetic resonance imaging (MRI) offers a radiation-free alternative with superior soft tissue visualization and functional insights. However, the lack of compatible instruments remains a major obstacle. An adapted thermal drawing platform that enables low-cost and rapid prototyping of instruments for MR-guided endovascular interventions is introduced. This platform is demonstrated through the development of two exemplary catheter systems: a tendon-driven steerable catheter with helical lumina and an active tracking Tiger-shaped catheter with an embedded coaxial wire. These catheters exhibit mechanical properties comparable to commercial counterparts and show promising outcomes in both in vitro and in vivo feasibility testing. This scalable thermal drawing platform addresses the limitations of existing manufacturing approaches and facilitates the exploration of diverse designs, potentially accelerating advancements in catheter technologies for MR-guided cardiovascular interventions.

摘要

心血管疾病(CVDs),包括先天性心脏病(CHD),是全球重大的健康挑战,凸显了对安全有效治疗方式的需求。荧光透视引导下的血管内介入治疗被广泛应用,但引发了对电离辐射的担忧,尤其是在儿科病例中。磁共振成像(MRI)提供了一种无辐射的替代方法,具有卓越的软组织可视化和功能洞察能力。然而,缺乏兼容的器械仍然是一个主要障碍。本文介绍了一种经过改进的热拉伸平台,该平台能够以低成本快速制作用于磁共振引导血管内介入治疗的器械原型。通过开发两种示例性导管系统展示了该平台:一种带有螺旋腔的腱驱动可转向导管和一种带有嵌入式同轴导线的主动跟踪虎形导管。这些导管的机械性能与商业同类产品相当,并且在体外和体内可行性测试中均显示出良好的结果。这种可扩展的热拉伸平台克服了现有制造方法的局限性,促进了对各种设计的探索,有可能加速磁共振引导心血管介入治疗导管技术的进步。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f2a/11615795/1a296d280f13/ADVS-11-2407704-g004.jpg

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