Zarroug Samah H O
Department of Pharmacology, College of Medicine, Alfaisal University, Riyadh11533, Saudi Arabia.
J Asian Nat Prod Res. 2025 Apr;27(4):577-590. doi: 10.1080/10286020.2024.2414189. Epub 2024 Oct 15.
The global aging population highlights the need for effective anti-aging treatments. Natural products show promise, but thorough evaluation requires models due to the complexity of aging. Ethical concerns are driving a shift from traditional models like rabbits and mice to alternatives such as . This microscopic nematode, with its short life cycle, genetic similarities to humans, and cost-effectiveness, is ideal for testing anti-aging compounds. We review studies using to assess natural products, suggesting it could serve as a primary model for -evaluating the safety and efficacy of plant-derived anti-aging compounds.
全球老龄化人口凸显了有效抗衰老治疗的必要性。天然产物显示出前景,但由于衰老的复杂性,全面评估需要模型。伦理问题正推动着从兔子和老鼠等传统模型向诸如……等替代模型的转变。这种微观线虫,因其生命周期短、与人类的基因相似性以及成本效益,是测试抗衰老化合物的理想选择。我们综述了使用……评估天然产物的研究,表明它可作为评估植物源抗衰老化合物安全性和有效性的主要模型。