Liao Vivian Hsiu-Chuan
Department of Bioenvironmental Systems Engineering, National Taiwan University , No. 1, Section 4, Roosevelt Road, Taipei 106, Taiwan.
J Agric Food Chem. 2018 Feb 28;66(8):1737-1742. doi: 10.1021/acs.jafc.7b05700. Epub 2018 Feb 12.
There is growing need and interest in finding specific compounds in natural products that have health benefits. Despite ongoing efforts to discover such compounds, the scientific evidence lags behind the vision, and it is important to find an effective paradigm for discovering such compounds. The model organism Caenorhabditis elegans offers a promising solution for studying the potential bioactivity and molecular mechanisms of natural compounds in vivo. This perspective discusses its use to study potential human health benefits, with focus on antioxidative, anti-aging, antimetabolic disorders (diabetes and obesity), and antineurodegenerative activities (Alzheimer's disease and Parkinson's disease), with practical examples. Finally, future directions in using a C. elegans-based model for discovering bioactive compounds for health promotion are discussed.
寻找具有健康益处的天然产物中的特定化合物的需求和兴趣日益增长。尽管一直在努力发现此类化合物，但科学证据仍落后于预期，因此找到一种有效的发现此类化合物的范式非常重要。模式生物秀丽隐杆线虫为研究天然化合物在体内的潜在生物活性和分子机制提供了一个有前景的解决方案。本文从抗氧化、抗衰老、抗代谢紊乱（糖尿病和肥胖症）以及抗神经退行性疾病（阿尔茨海默病和帕金森病）等方面，结合实际例子，探讨了利用秀丽隐杆线虫研究对人类潜在健康益处的方法。最后，讨论了使用基于秀丽隐杆线虫的模型发现促进健康的生物活性化合物的未来方向。
