Rašeta Milena, Mišković Jovana, Krsmanović Nenad, Čapelja Eleonora, Berežni Sanja, Pintać Šarac Diandra, Karaman Maja
Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia.
ProFungi Laboratory, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia.
Nat Prod Res. 2024 Oct 15:1-12. doi: 10.1080/14786419.2024.2415437.
This study explores the bioactivity potential of four indigenous species from northern Serbia (, , , and ), comparing antioxidant and anti-acetylcholinesterase (anti-AChE) properties. The mycochemical profile, including ethanol (EtOH), water (HO), and chloroform (CHCl) extracts, was analysed, revealing significant phenolic compounds, such as 2,5-dihydroxybenzoic acid. Highest total phenolic content (TP) was in EtOH extracts (205 - 380 mg GAE/g d.w.), and total carbohydrate content peaked in CHCl extracts (1895 ± 0.29 mg GluE/g d.w., 439 ± 0.42 mg FruE/g d.w.). DPPH and FRAP activities were prominent in HO extracts, while CHCl extracts excelled in the NO assay, and EtOH extracts were superior in the ABTS assay. The most effective AChE inhibitors were polar extracts from . These findings emphasise the potential therapeutic use of species, particularly in combating oxidative stress and acetylcholine deficiencies.
本研究探索了塞尔维亚北部四种本土物种（、、和）的生物活性潜力，比较了其抗氧化和抗乙酰胆碱酯酶（抗AChE）特性。分析了包括乙醇（EtOH）、水（HO）和氯仿（CHCl）提取物在内的真菌化学概况，发现了重要的酚类化合物，如2,5 - 二羟基苯甲酸。乙醇提取物中的总酚含量（TP）最高（205 - 380毫克没食子酸当量/克干重），而氯仿提取物中的总碳水化合物含量最高（1895±0.29毫克葡萄糖当量/克干重，439±0.42毫克果糖当量/克干重）。水提取物中的DPPH和FRAP活性显著，而氯仿提取物在NO检测中表现出色，乙醇提取物在ABTS检测中更具优势。最有效的AChE抑制剂是来自的极性提取物。这些发现强调了这些物种的潜在治疗用途，特别是在对抗氧化应激和乙酰胆碱缺乏方面的作用。
