Abu-Hamdan D K, Mahajan S K, Migdal S D, Prasad A S, McDonald F D
Ann Intern Med. 1986 Jan;104(1):50-2. doi: 10.7326/0003-4819-104-1-50.
The effects of ferrous sulfate and aluminum hydroxide on the oral zinc tolerance test after administration of 25 mg of elemental zinc as sulfate were studied in six hemodialysis patients and six normal controls. Fasting plasma zinc levels, the 2-hour plasma zinc peak, and the area under the plasma zinc curve were significantly lower in patients compared with values in controls (plasma zinc, 92 +/- 4 compared with 108 +/- 3 micrograms/dL, p less than 0.025; 2-hour plasma zinc peak, 159 +/- 8 compared with 228 +/- 17 micrograms/dL, p less than 0.025; and area under the curve, 193 +/- 41 compared with 316 +/- 39 micrograms h/dL, p less than 0.025). Ferrous sulfate (300 mg orally), when administered along with zinc sulfate, decreased the area under the curve significantly (in patients by 28%, in controls by 40%) in comparison with the results obtained when zinc sulfate was given alone. When 30 mL of aluminum hydroxide was administered orally with zinc sulfate, the area under the curve decreased by 60% in controls and 75% in patients (p less than 0.005). These results confirm the presence of diminished zinc absorption in patients with renal failure and show that ferrous sulfate and aluminum hydroxide, which worsen this defect, also impair zinc absorption in normal subjects.
研究了六名血液透析患者和六名正常对照者在口服25毫克硫酸锌形式的元素锌后，硫酸亚铁和氢氧化铝对口服锌耐量试验的影响。与对照组相比，患者的空腹血浆锌水平、2小时血浆锌峰值和血浆锌曲线下面积显著降低（血浆锌：患者为92±4，对照组为108±3微克/分升，p<0.025；2小时血浆锌峰值：患者为159±8，对照组为228±17微克/分升，p<0.025；曲线下面积：患者为193±41，对照组为316±39微克·小时/分升，p<0.025）。硫酸亚铁（口服300毫克）与硫酸锌一起给药时，与单独给予硫酸锌相比，曲线下面积显著降低（患者降低28%，对照组降低40%）。当30毫升氢氧化铝与硫酸锌一起口服时，对照组曲线下面积降低60%，患者降低75%（p<0.005）。这些结果证实了肾衰竭患者存在锌吸收减少的情况，并表明硫酸亚铁和氢氧化铝会加重这种缺陷，它们在正常受试者中也会损害锌的吸收。
